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HIV/AIDS
The online home of AIDS Clinical Care. Stay informed on the changing landscape of HIV care with perspectives on the latest research, antiretroviral alerts, and succinct case discussions from our expert clinicians.
Resistance: What You Don’t Know — Can It Hurt You?
- Antiretroviral Rounds
- Free
Two experts weigh in on whether to switch regimens in a patient with evidence of triple-class resistance.
- May 5, 2008
Does Viral-Load Testing Reduce Drug Resistance in Resource-Poor Settings?
- Summary and Comment
- Free
Despite viral-load testing, high levels of drug resistance at first virologic failure were found in KwaZulu-Natal, South Africa.
- By Renslow Sherer, MD
- May 5, 2008
- Covering Clin Infect Dis 2008 May 15
Cefixime Tablets Available in the U.S. Again
- Drug Watch
- Subscription required
Cefixime tablets (Suprax; 400 mg) are now available in the U.S. for the first time since 2002. Cefixime is the only
- By ACC Editors
- May 5, 2008
Both Fish Oil and Fibrates Reduce Triglyceride Levels
- Summary and Comment
- Subscription required
Both fish oil and fenofibrate safely reduce elevated triglyceride levels in HIV-infected patients receiving ART.
- By Keith Henry, MD
- April 28, 2008
- Covering J Acquir Immune Defic Syndr 2008 Apr 1
Caution Urged When Combining Lopinavir/Ritonavir and Rosuvastatin
- Summary and Comment
- Subscription required
In a pharmacokinetic study involving 20 healthy volunteers, coadministration of lopinavir/ritonavir and rosuvastatin significantly increased rosuvastatin levels yet attenuated the LDL-lowering effect of the drug; one study participant experienced a grade 4 elevation in creatinine phosphokinase levels.
- By Keith Henry, MD
- April 28, 2008
- Covering J Acquir Immune Defic Syndr 2008 Apr 15
Rapid ART Scale-Up Needed in South Africa
- Summary and Comment
- Subscription required
A mathematical model to estimate the effect of different antiretroviral scale-up scenarios suggests that rapid scale-up is critical if universal access is to be achieved during the next 5 years for all people in need of treatment.
- By Salim S. Abdool Karim, MD, PhD
- April 28, 2008
- Covering J Infect Dis 2008 May 1
Emergence of the K65R Mutation with NNRTI-Based Regimens
- Summary and Comment
- Subscription required
In the Swiss HIV Cohort Study, emergence of the K65R mutation was significantly associated with tenofovir-containing regimens that were anchored by NNRTIs rather than by PIs.
- By Manish Sagar, MD
- April 18, 2008
- Covering Clin Infect Dis 2008 Apr 15
Nevirapine Hypersensitivity
- Summary and Comment
- Subscription required
Data from a large cohort study in the Netherlands help identify which treatment-experienced patients are most likely to develop nevirapine hypersensitivity reactions.
- By Helmut Albrecht, MD
- April 18, 2008
- Covering Clin Infect Dis 2008 Mar 15
Discordant Responses to ART
- Summary and Comment
- Subscription required
Patients who have either complete virologic control or good immunologic recovery, but not both, have higher risk for opportunistic infection or death than do patients who show favorable responses in both parameters.
- By Helmut Albrecht, MD
- April 18, 2008
- Covering J Acquir Immune Defic Syndr 2008 Apr 15
More Reassuring Data About Pregnancy in HIV-Infected Women
- Summary and Comment
- Subscription required
In the current treatment era, survival rates are high for HIV-infected mothers, and vertical transmission rates are low.
- By Sonia Nagy Chimienti, MD
- April 18, 2008
- Covering HIV Clin Trials 2008 Jan/Feb
Abacavir and ddI Linked to Increased MI Risk
- Summary and Comment
- Subscription required
In a surprising finding from the DAD Study, recent use of abacavir or ddI was associated with increased risk for myocardial infarction.
- By Keith Henry, MD
- April 14, 2008
- Covering Lancet 2008 Apr 2
Editor's Picks from across Journal Watch
Am I Passing MRSA to My Patients?
- Emergency Medicine
- Summary and Comment
- Free
A literature review finds that healthcare workers play a role in MRSA transmission, and the authors make screening recommendations.
- By Kristi L. Koenig, MD, FACEP
- April 18, 2008
- Covering Lancet Infect Dis 2008 May
Trichomoniasis — Just Another Nuisance?
- Women's Health
- Summary and Comment
- Subscription required
The common STI, trichomoniasis vaginalis, could have considerable consequences.
- By Anna Wald, MD, MPH
- April 17, 2008
- Covering J Infect Dis 2008 Feb 15
Trends in MRSA Carriage in the U.S.
- Infectious Diseases
- Summary and Comment
- Subscription required
The prevalence of nasal colonization is increasing.
- By Daniel J. Diekema, MD, MS
- April 23, 2008
- Covering J Infect Dis 2008 May 1
Rapid Screening for MDR-TB
- Infectious Diseases
- Summary and Comment
- Free
A molecular probe was 
99% sensitive and specific for multidrug TB resistance, compared with standard drug-susceptibility testing; results were available in 1 to 2 days.
- By Neil M. Ampel, MD
- April 23, 2008
- Covering Am J Respir Crit Care Med 2008 Apr 1
Jounal Watch HIV/AIDS summarizes important medical journal articles about a wide variety of HIV-related subjects including acute HIV infection, antiretroviral resistance, epidemiology, hepatitis, initial therapy, medication adherence, opportunistic infections, and STDs.
