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HIV/AIDS Clinical Care

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HIV/AIDS Clinical Care Supporting Image

ANTIRETROVIRAL ROUNDS

Is She or Isn't She?Free

An HIV-infected pregnant woman says she's taking her antiretrovirals — but the blood test results say otherwise. How would you manage?

Recent HIV/AIDS Clinical Care Articles

SUMMARY AND COMMENT

Initial Antiretroviral Therapy — Switching Still Common

In an observational cohort study, treatment changes within the first year of therapy were common but did not reduce rates of virologic suppression.

SUMMARY AND COMMENT

Transmitted HIV Drug Resistance — The Role of an Ultra-Sensitive Assay

In this prospective study, 20% of treatment-naive patients had minority drug-resistance mutations detected on an ultra-sensitive assay, but the presence of such mutations did not lead to worse outcomes.

AIDS WATCH

ddI and Portal Hypertension

The FDA has concluded that ddI use is associated with the development of noncirrhotic portal hypertension. Forty-two cases have been reported, including several that led . . .

SUMMARY AND COMMENT

TB Recurrence: Reinfection or Relapse?Free

Recurrences after successful TB treatment are more common among HIV-positive than HIV-negative patients, and the reasons are different: About half the recurrences in HIV-positive patients represent reinfection rather than reactivation.

SUMMARY AND COMMENT

More from the DAD Study on Antiretrovirals and MI Risk

An increased risk for myocardial infarction was found with recent exposure to abacavir and ddI and with cumulative exposure to abacavir, indinavir, and lopinavir/ritonavir.

SUMMARY AND COMMENT

Isoniazid Prophylaxis in HIV-Infected PatientsFree

HIV-infected patients who received isoniazid preventive therapy as part of a clinical trial in Botswana had low rates of incident tuberculosis and severe adverse events; adherence was quite high.

SUMMARY AND COMMENT

No Benefit for Directly Observed Antiretroviral Therapy

In a meta-analysis, viral suppression was similar in observed and nonobserved patients.

SUMMARY AND COMMENT

Pooled NAAT Following Various HIV Antibody TestsFree

Pooled NAAT can improve detection of HIV infection, even when highly sensitive third-generation immunoassays are used for initial antibody testing.

SUMMARY AND COMMENT

Predictors of Non-Hodgkin Lymphoma in HIV-Infected Patients

Low CD4-cell counts and high-level viremia were each associated with increased NHL risk in a cohort of HIV-infected individuals.

SUMMARY AND COMMENT

Prevalence and Incidence of HBV Infection in an HIV-Positive Cohort

Hepatitis B virus infection continues to be a major problem in a U.S. military cohort of HIV-infected individuals. More effective "prevention for positives" is needed.

Browse our complete HIV/AIDS Clinical Care archive >>

Editor's Picks from across Journal Watch

SUMMARY AND COMMENT

Adherence to ID Specialists' Recommendations?

Community-acquired infection, advice on antibiotic nonuse or discontinuation, and recommendations for performing monitoring tests were associated with higher rates of adherence.

SUMMARY AND COMMENT

Drug-Resistant TB Among Gold Miners in South AfricaFree

Among gold miners in South Africa (many of them HIV infected), TB drug resistance spread despite treatment adherence.

SUMMARY AND COMMENT

What Patients Don't Know Might Hurt Them

Patients are alarmingly unaware of medications that are prescribed to them in the hospital.

SUMMARY AND COMMENT

Steroids Might Benefit Critically Ill Patients with Suspected H1N1 Influenza

Combined treatment with antiviral agents and steroids led to significant improvements in organ function within 1 week.

More Editor's Picks >>

Jounal Watch HIV/AIDS Clinical Care summarizes important medical journal articles about a wide variety of HIV-related subjects including acute HIV infection, antiretroviral resistance, epidemiology, hepatitis, initial therapy, medication adherence, opportunistic infections, and STDs.

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Aids Clinical Care Editor-in-Chief

Paul E. Sax, MD
Paul E. Sax, MD
Clinical Director, HIV Program and Division of Infectious Diseases, Brigham and Women’s Hospital

More about Journal Watch HIV/AIDS and its board >>

Journals Watched: HIV/AIDS >>

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Physician's First Watch
February 8, 2010

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