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HIV/AIDS Clinical Care
Journal Watch condenses summaries of key research across specialties from more than 250 medical journals into concise yet comprehensive articles, incorporating clinical commentary from prominent physician-editors in the field.
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Featured Article
SUMMARY AND COMMENT
Preventing HBV Infection with ARTFree
- May 24, 2013
- Helmut Albrecht, MD
Antiretroviral regimens containing 3TC, tenofovir, or both, reduced the risk for incident hepatitis B virus infection by approximately 90% compared with other or no antiretrovirals.
- Reviewing:
- Gatanaga H et al. Clin Infect Dis 2013 Jun 15; 56:1812
Recent HIV/AIDS Clinical Care Articles
SUMMARY AND COMMENT
Functional Impairment in HIV-Infected Patients
- May 24, 2013
- Rajesh T. Gandhi, MD
In patients on suppressive antiretroviral therapy, greater CD8-cell activation and higher interleukin-6 level are associated with functional impairment.
- Reviewing:
- Erlandson KM et al. J Infect Dis 2013 May 6
FEATURE
ID Learning Unit — "Isolator" Blood CulturesFree
- May 24, 2013
In his blog HIV and ID Observations, Dr. Paul Sax explains the indications for an obscure blood test used by ID consultants.
SUMMARY AND COMMENT
Another Step Toward Eliminating HIV Infection?Free
- May 20, 2013
- David Margolis, MD
In two patients, allogeneic stem-cell transplantation under the cover of ART produced sustained reduction of HIV reservoirs in peripheral blood mononuclear cells.
- Reviewing:
- Henrich TJ et al. J Infect Dis 2013 Jun 1; 207:1694
SUMMARY AND COMMENT
Major Decline in CD4-Cell Count in Virally Suppressed Patients Signals Threat to Health
- May 20, 2013
- Keith Henry, MD
In a cohort of HIV-infected patients on ART with suppressed viral load, sustained CD4-cell count declines were associated with increased risk for morbidity and death.
- Reviewing:
- Helleberg M et al. Clin Infect Dis 2013 May 6
SUMMARY AND COMMENT
In Some Areas, Lipodystrophy Afflicts Most ART Recipients
- May 20, 2013
- Abigail Zuger, MD
A study conducted in France found that more than 80% are affected.
- Reviewing:
- Leclercq P et al. AIDS Res Hum Retroviruses 2013 May; 29:761
FEATURE
ID Learning Unit — Antibiotics with Excellent Oral AbsorptionFree
- May 20, 2013
In his blog HIV and ID Observations, Dr. Paul Sax makes the case for oral antibiotics.
SUMMARY AND COMMENT
Predictors of Response to Second-Line Therapy — Do the NRTIs Matter?Free
- May 13, 2013
- Kevin L. Ard, MD, MPH, and Paul E. Sax, MD
A retrospective analysis suggests that treatment failure on a second-line regimen is as common with one or more new nucleoside reverse-transcriptase inhibitors as with none.
- Reviewing:
- Waters L et al. Antivir Ther 2013 ; 18:213
SUMMARY AND COMMENT
Incident HCV Infection in MSM
- May 13, 2013
- Carlos del Rio, MD
Hepatitis C virus infection has occurred among men who have sex with men since the beginning of the HIV epidemic, with higher rates of infection among those who are HIV-infected.
- Reviewing:
- Witt MD et al. Clin Infect Dis 2013 Apr 22
GUIDELINE WATCH
HIV Opportunistic Infection Guidelines, Updated
- May 13, 2013
- Paul E. Sax, MD
These guidelines, last revised in 2009, are comprehensive, exhaustively referenced, and authoritative.
FEATURE
FDA: Fecal Transplants Need Investigational New Drug ApplicationFree
- May 13, 2013
In his blog HIV and ID Observations, Dr. Paul Sax weighs in on a recent FDA decision regarding fecal microbiota transplantation.
Journal Watch HIV/AIDS Clinical Care summarizes important medical journal articles about a wide variety of HIV-related subjects including acute HIV infection, antiretroviral resistance, epidemiology, hepatitis, initial therapy, medication adherence, opportunistic infections, and STDs.
