- Home>
- Specialties>
- HIV/AIDS Clinical Care
HIV/AIDS Clinical Care
Journal Watch condenses summaries of key research across specialties from more than 250 medical journals into concise yet comprehensive articles, incorporating clinical commentary from prominent physician-editors in the field.
Sign up now for free weekly e-mail alerts featuring the full text of one article and links to new articles on the most clinically relevant news, new guidelines, and research from the HIV/AIDs journal literature.
Featured Article
SUMMARY AND COMMENT
ART Reduces TB Risk, Even in High-Income CountriesFree
- May 14, 2012
- Carlos del Rio, MD
However, the benefit is not seen in patients who start ART at very low CD4-cell counts.
- Reviewing:
- The HIV-CAUSAL Collaboration. Clin Infect Dis 2012 May 1; 54:1364
Recent HIV/AIDS Clinical Care Articles
FEATURE
Advisory Meeting on Tenofovir/FTC for PrEP, and a Proposed "Niche" for its UseFree
- May 14, 2012
In his blog HIV and ID Observations, Dr. Paul Sax describes one scenario in which pre-exposure prophylaxis "makes a whole lot of sense."
SUMMARY AND COMMENT
Frequent Virologic Monitoring Limits NRTI and NNRTI ResistanceFree
- May 7, 2012
- Salim S. Abdool Karim, MD, PhD
Ongoing virologic monitoring, along with strict application of criteria for regimen switches, was associated with low rates of resistance to nucleoside and nonnucleoside reverse transcriptase inhibitors, which in turn preserved second-line treatment options.
- Reviewing:
- Barth RE et al. Antivir Ther 2012 ; 17:377
SUMMARY AND COMMENT
Dolutegravir Holds Promise
- May 7, 2012
- Helmut Albrecht, MD
In a 48-week, phase II study, this investigational integrase inhibitor was as effective as efavirenz and better tolerated.
- Reviewing:
- van Lunzen J et al. Lancet Infect Dis 2012 Feb; 12:111
SUMMARY AND COMMENT
Premature Aging with HIV Infection: More Evidence
- May 7, 2012
- Nina H. Lin, MD
Despite antiretroviral therapy, young HIV-positive patients had the same monocyte defects as older HIV-negative controls.
- Reviewing:
- Hearps AC et al. AIDS 2012 Apr 24; 26:843
SUMMARY AND COMMENT
Funding HIV Activities at the State Level: Is There a Better Way?
- May 7, 2012
- Keith Henry, MD
The amount of funding that states receive may not adequately reflect the relative burden of disease they face.
- Reviewing:
- Mansergh G et al. J Acquir Immune Defic Syndr 2012 Apr 15; 59:516
SUMMARY AND COMMENT
PrEP in MSM: Enough Bang for the Buck?
- April 30, 2012
- Rochelle P. Walensky, MD, MPH
PrEP may be cost-effective, particularly in high-risk MSM, but many questions remain.
- Reviewing:
- Juusola JL et al. Ann Intern Med 2012 Apr 17; 156:541
SUMMARY AND COMMENT
More Evidence that Tenofovir Leads to Bone Loss
- April 30, 2012
- Sonia Nagy Chimienti, MD
Patients who switched to tenofovir from AZT experienced significant decreases in BMD. Those who switched to abacavir did not.
- Reviewing:
- Rasmussen TA et al. PLoS ONE 2012 Mar 29; 7:e32445
SUMMARY AND COMMENT
How Well Do MDs Follow HIV Treatment Guidelines?
- April 30, 2012
- Abigail Zuger, MD
In Australia, they did well in some things, poorly in others.
- Reviewing:
- Bloch M et al. J Acquir Immune Defic Syndr 2012 Apr 15; 59:478
FEATURE
Do We Really Need Primary Prophylaxis for OIs Anymore?Free
- April 30, 2012
Maybe not, says Dr. Paul Sax in his blog HIV and ID Observations.
SUMMARY AND COMMENT
Undetectable Viral Load — Not a Guarantee Against Transmitting HIVFree
- April 23, 2012
- Charles B. Hicks, MD
Detectable HIV RNA in semen concurrent with undetectable plasma HIV RNA is not an uncommon event, a finding which may have implications for HIV transmission.
- Reviewing:
- Lambert-Niclot S et al. AIDS 2012 Feb 29
Editor's Picks from across Journal Watch
SUMMARY AND COMMENT
Time to Broaden HCV Testing?
- May 8, 2012
- By Abigail Zuger, MD
- General Medicine
Improvements in treatment are changing the calculus of screening the general population for hepatitis C virus infection.
- Reviewing:
- Clin Infect Dis 2012 May 1; 54:1259
SUMMARY AND COMMENT
New Tests Predict Clinical Outcomes in Chronic Hepatitis C VirusFree
- May 4, 2012
- By Atif Zaman, MD, MPH
- Gastroenterology
A battery of quantitative liver-function tests might provide a noninvasive method of risk assessment.
- Reviewing:
- Hepatology 2012 Apr; 55:1019
SUMMARY AND COMMENT
A Review of Drug Interactions of Telaprevir and Boceprevir
- May 11, 2012
- By Atif Zaman, MD, MPH
- Gastroenterology
A compendium of information on how these protease inhibitors interact with other drugs often needed by patients with HCV infection
- Reviewing:
- Hepatology 2012 May; 55:1620
SUMMARY AND COMMENT
A Recombinant Vaccine for Tuberculosis
- May 2, 2012
- By Neil M. Ampel, MD
- Infectious Diseases
In a phase IIa trial, vaccination with MVA85A was well tolerated and induced T-cell responses in individuals with HIV infection, Mtb infection, or both.
- Reviewing:
- Am J Respir Crit Care Med 2012 Apr 1; 185:769
Journal Watch HIV/AIDS Clinical Care summarizes important medical journal articles about a wide variety of HIV-related subjects including acute HIV infection, antiretroviral resistance, epidemiology, hepatitis, initial therapy, medication adherence, opportunistic infections, and STDs.
