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HIV/AIDS Clinical Care
Journal Watch condenses summaries of key research across specialties from more than 250 medical journals into concise yet comprehensive articles, incorporating clinical commentary from prominent physician-editors in the field.
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Featured Article
SUMMARY AND COMMENT
Virologic Failure on Rilpivirine May Lead to Broad NNRTI Resistance
- January 23, 2012
- Charles B. Hicks, MD
In the ECHO and THRIVE trials, 10% of the patients who received rilpivirine-based regimens experienced treatment failure. Nearly half of these patients developed resistance to multiple nonnucleoside reverse transcriptase inhibitors.
- Reviewing:
- Rimsky L et al. J Acquir Immune Defic Syndr 2012 Jan 1; 59:39
Recent HIV/AIDS Clinical Care Articles
SUMMARY AND COMMENT
Bone Fragility Does Indeed Mean More Fractures
- January 23, 2012
- Abigail Zuger, MD
A study in Denmark demonstrated an increased risk for osteoporotic fractures in HIV-infected patients and implicated antiretroviral therapy as a risk factor.
- Reviewing:
- Hansen A-BE et al. AIDS 2012 Jan 28; 26:285
FEATURE
Generic Lamivudine Has ArrivedFree
- January 23, 2012
Dr. Paul Sax marks the significance of this event in his blog HIV and ID Observations.
SUMMARY AND COMMENT
Even at High CD4-Cell Counts, Mortality Rates Are High in Untreated HIV InfectionFree
- January 13, 2012
- Mauro Schechter, MD, PhD
An observational study from Côte d'Ivoire supports earlier treatment initiation, particularly in sub-Saharan Africa.
- Reviewing:
- Anglaret X et al. Clin Infect Dis 2011 Dec 14
SUMMARY AND COMMENT
In Early HIV Infection, Little Reason to Delay Therapy
- January 13, 2012
- Paul E. Sax, MD
In a large randomized trial, half the patients who deferred therapy during early infection required treatment within 18 months.
- Reviewing:
- Hogan CM et al. J Infect Dis 2012 Jan 1; 205:87
SUMMARY AND COMMENT
A Combined HIV Antigen/Antibody Rapid Test Fails Field Evaluation
- January 13, 2012
- Abigail Zuger, MD
Diagnosis of acute HIV infection remains elusive.
- Reviewing:
- Rosenberg NE et al. J Infect Dis 2011 Dec 29
SUMMARY AND COMMENT
Renal Function in HIV-Infected Patients Receiving Tenofovir-Containing Regimens
- January 13, 2012
- Rajesh T. Gandhi, MD
Patients treated with tenofovir/FTC + ritonavir-boosted atazanavir had a greater decline in renal function than those treated with tenofovir/FTC + efavirenz.
- Reviewing:
- Albini L et al. J Acquir Immune Defic Syndr 2012 Jan 1; 59:18
SUMMARY AND COMMENT
In Utero Tenofovir Exposure Shows No Effect on Infant Bone Health
- January 13, 2012
- Keith Henry, MD
The findings of a new cross-sectional study are somewhat reassuring but require validation.
- Reviewing:
- Viganò A et al. Antivir Ther 2011 ; 16:1259
SUMMARY AND COMMENT
Is HIV Becoming More Virulent?
- January 13, 2012
- Helmut Albrecht, MD
A meta-analysis suggests that over the course of the epidemic, the mean virologic set point of HIV-infected patients has been increasing and the mean baseline CD4-cell count has been decreasing.
- Reviewing:
- Herbeck JT et al. AIDS 2012 Jan 14; 26:193
FEATURE
First Rabies Case in State in Over 75 Years Raises Questions (Again) About Preventive StrategiesFree
- January 13, 2012
In his blog HIV and ID Observations, Dr. Paul Sax revisits the question of whether to immunize for "bat-in-the-bedroom" exposures.
LETTER TO READERS
HIV/AIDS Year in Review 2011Free
- December 30, 2011
- Paul E. Sax, MD
Our physician-editors offer their perspective on the year's most important stories in HIV medicine.
Editor's Picks from across Journal Watch
SUMMARY AND COMMENT
New Antivirals Show Promise for an Interferon-Free Hepatitis C Treatment
- January 18, 2012
- By Atif Zaman, MD, MPH
- Gastroenterology
Patients with HCV genotype 1 and previous null response achieved a 36% sustained virologic response at 24 weeks of therapy with daclatasvir and asunaprevir alone.
- Reviewing:
- N Engl J Med 2012 Jan 19; 366:216
SUMMARY AND COMMENT
Effective Short-Course Treatment for Latent Tuberculosis
- December 20, 2011
- By Abigail Zuger, MD
- General Medicine
Three months of isoniazid plus rifapentine worked as well as 9 months of isoniazid.
- Reviewing:
- N Engl J Med 2011 Dec 8; 365:2155
CLINICAL PRACTICE GUIDELINE WATCH
Recommendations for Use of Short-Course Isoniazid-Rifapentine for Latent TBFree
- December 21, 2011
- By Stephen G. Baum, MD
- Infectious Diseases
This two-drug regimen, administered weekly for just 12 weeks, is efficacious in preventing active disease in patients with latent Mycobacterium tuberculosis infection.
- Reviewing:
- MMWR Morb Mortal Wkly Rep 2011 Dec 9; 60:1650
SUMMARY AND COMMENT
Low Vitamin D Levels Linked to Active TuberculosisFree
- November 30, 2011
- By Richard T. Ellison III, MD
- Infectious Diseases
Seasonal declines in mean vitamin D levels were followed by seasonal increases in TB notifications.
- Reviewing:
- Proc Natl Acad Sci U S A 2011 Nov 22; 108:19013
Journal Watch HIV/AIDS Clinical Care summarizes important medical journal articles about a wide variety of HIV-related subjects including acute HIV infection, antiretroviral resistance, epidemiology, hepatitis, initial therapy, medication adherence, opportunistic infections, and STDs.
