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Search for Acute Infection in HIV/AIDS Clinical Care
Physician-authored summaries on the latest research on acute infection, editorials on acute infection, and perspectives on acute infection - drawn from the top medical journals.
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You searched for: acute infection in HIV/AIDS
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Nucleic-Acid Amplification Testing Might Improve Detection of Acute Infection
- May 11, 2005
- Charles B. Hicks, MD
- HIV/AIDS
Adding nucleic-acid testing to standard antibody testing improved the detection of acute HIV infection in North Carolina — and was cost-effective.- Reviewing:
- Pilcher CD et al., N Engl J Med 2005 May 5; 352:1873-83.
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Massive CD4+ T cell Depletion in Acute Infection
- April 13, 2005
- Timothy Lahey, MD
- HIV/AIDS
Two animal studies document massive and rapid depletion of CD4+ memory T cells in the blood and intestinal mucosa during acute infection.- Reviewing:
- Mattapallil JJ et al., Nature 2005 Mar 27;: Li Q et al., Nature 2005 Mar 27;:
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No Clear Benefit of Antiretroviral Therapy for Acute Infection: More Evidence
- February 1, 2005
- Keith Henry, MD
- HIV/AIDS
Comparison of treated versus untreated patients identified during acute infection found no significant difference in viral loads an estimated 36 months after infection.- Reviewing:
- Desquilbet L et al., AIDS 2004 Dec 3; 18:2361-9.
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High Semen HIV Levels During Acute Infection May Shape Epidemic
- August 1, 2004
- Abigail Zuger, MD
- HIV/AIDS
During acute HIV infection, high semen levels of the virus make men "biologically hyperinfectious;" a sizeable fraction of sexual transmission of HIV may take place during this time.- Reviewing:
- Pilcher CD et al., J Infect Dis 2004 May 15; 189:1785-92.
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Untangling the Sequence of Events in Acute Infection
- November 1, 2003
- Deborah J. Cotton, MD, MPH
- HIV/AIDS
Researchers examined samples from blood donors with acute infection to determine which tests show what and when. -
Risk for Vertical Postpartum HIV Transmission During Acute Infection
- August 24, 2009
- Sonia Nagy Chimienti, MD
- HIV/AIDS
In a retrospective case series of women who acquired HIV from postpartum blood transfusions, the absolute risk for transmitting HIV vertically through breast-feeding was 36%.- Reviewing:
- Liang K et al., J Infect Dis 2009 Sep 1; 200:682. Lockman S and Creek T., J Infect Dis 2009 Sep 1; 200:667.
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Identifying Patients with Acute HIV Infection and Their Partners
- August 10, 2009
- Sonia Nagy Chimienti, MD
- HIV/AIDS
In North Carolina, a protocol for negative or indeterminate HIV-antibody results that involved nucleic acid amplification testing, confirmatory antibody testing, and follow-up interviews led to identification of newly infected partners of newly infected patients.- Reviewing:
- Moore ZS et al., J Acquir Immune Defic Syndr 2009 Jun 26;:
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Stuck in the Middle Free
- July 27, 2009
- HIV/AIDS
A clinician sustains a needlestick from a patient who refuses HIV testing. An HIV physician, an attorney, and an ethicist weigh provide weigh in on how best to manage. -
Which HIV Test Is Best in High-Incidence Groups?
- July 27, 2009
- Carlos del Rio, MD
- HIV/AIDS
In a study of specimens from Seattle-area MSM, a rapid antibody test detected HIV infection less well than did either enzyme immunoassay antibody testing or nucleic-acid amplification testing.- Reviewing:
- Stekler JD et al., Clin Infect Dis 2009 Aug 1; 49:444.
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HIV Testing — Targeting High-Risk Populations
- June 1, 2009
- Charles B. Hicks, MD
- HIV/AIDS
In an innovative program of bathhouse-based HIV testing, 4% of participants were found to be HIV-infected.- Reviewing:
- Daskalakis D et al., Clin Infect Dis 2009 Jun 1; 48:1609.
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What Happens When PEP or PrEP Fails?
- September 29, 2008
- Raphael J. Landovitz, MD
- HIV/AIDS
A case report provides at least some reassurance that failure of antiretroviral prophylaxis does not necessarily result in drug resistance.- Reviewing:
- Prada N et al., J Acquir Immune Defic Syndr 2008 Sep 2;:
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Continued Problems with Late HIV Diagnosis and New Problems with Testing Scale-Up
- March 10, 2008
- Carlos del Rio, MD
- HIV/AIDS
Several reports presented at the 15th Retrovirus Conference highlighted ongoing challenges with HIV testing. -
Limitations of Rapid Testing Free
- July 16, 2007
- Rochelle P. Walensky, MD, MPH
- HIV/AIDS
The performance characteristics of a sequential rapid HIV-testing algorithm were poorer than anticipated in a Ugandan study, perhaps due to false-positive results from tests with “faint bands.”- Reviewing:
- Gray RH et al., BMJ 2007 Jun 1;:
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Primary HIV Infection — Predicting the Set Point Free
- June 18, 2007
- Charles B. Hicks, MD
- HIV/AIDS
Having a greater number of symptoms during primary infection was associated with a higher initial viral load, which, in turn, was associated with a higher viral set point.- Reviewing:
- Kelley CF et al., J Acquir Immune Defic Syndr 2007 May 17;:
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A Single Case of Patient-to-Patient HBV Transmission in an Oral Surgery Center
- May 14, 2007
- Rachel Baden, MD
- HIV/AIDS
The case occurred despite apparent adherence to standard infection control measures and vaccination of nearly all healthcare personnel.- Reviewing:
- Redd JT et al., J Infect Dis 2007 May 1; 195:1311-4. Allos BM and Schaffner W., J Infect Dis 2007 May 1; 195:1245-7.
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Resistance Testing: A New Emphasis on Detecting Transmitted Resistance Free
- December 29, 2006
- HIV/AIDS
All HIV-infected patients should undergo genotype testing prior to initiation of antiretroviral therapy. -
Improving Diagnosis of Acute HIV Infection
- December 18, 2006
- Charles B. Hicks, MD
- HIV/AIDS
A growing body of evidence supports the use of nucleic-acid amplification testing to improve diagnosis of acute infection.- Reviewing:
- Truong HH et al., AIDS 2006 Nov 14; 20:2193-7. Priddy FH et al., J Acquir Immune Defic Syndr 2006 Nov 30;:
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Treatment of Acute HIV Infection
- October 2, 2006
- G. Sonia Nagy, MD
- HIV/AIDS
Two small, nonrandomized studies fall short of providing clear answers about whether to initiate potent combination antiretroviral therapy at a very early stage of infection.- Reviewing:
- Hecht FM et al., J Infect Dis 2006 Sep 15; 194:725-33. Streeck H et al., J Infect Dis 2006 Sep 15; 194:734-9. Kinloch-de Loes S., J Infect Dis 2006 Sep 15; 194:721-4.
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DHHS Treatment Guidelines Updated
- May 10, 2006
- Abigail Zuger, MD
- HIV/AIDS
New HIV treatment guidelines include updates on genotypic resistance testing and treatment interruptions.- Reviewing:
- ,;:
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Transmitted Resistance in the CASCADE Collaboration
- January 4, 2006
- Charles B. Hicks, MD
- HIV/AIDS
Transmitted HIV-drug resistance appears to have increased over time in a large cohort from Europe and Canada, but what actually constitutes significant antiretroviral drug resistance?- Reviewing:
- Masquelier B et al., J Acquir Immune Defic Syndr 2005 Dec 15; 40:505-11.
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