Search for Acute Infection in HIV/AIDS Clinical Care

Physician-authored summaries on the latest research on acute infection, editorials on acute infection, and perspectives on acute infection - drawn from the top medical journals.

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Nucleic-Acid Amplification Testing Might Improve Detection of Acute Infection
- May 11, 2005
- Charles B. Hicks, MD
- HIV/AIDS
Adding nucleic-acid testing to standard antibody testing improved the detection of acute HIV infection in North Carolina — and was cost-effective.
- Reviewing:
- Pilcher CD et al., N Engl J Med 2005 May 5; 352:1873-83.
- Related Searches: hiv, hiv infection syndrome, acute, hiv screen, nucleic acid amplification tests
Massive CD4+ T cell Depletion in Acute Infection
- April 13, 2005
- Timothy Lahey, MD
- HIV/AIDS
Two animal studies document massive and rapid depletion of CD4+ memory T cells in the blood and intestinal mucosa during acute infection.
- Reviewing:
- Mattapallil JJ et al., Nature 2005 Mar 27;: Li Q et al., Nature 2005 Mar 27;:
- Related Searches: cd4 count determination procedure, hiv, hiv infection syndrome, acute
No Clear Benefit of Antiretroviral Therapy for Acute Infection: More Evidence
- February 1, 2005
- Keith Henry, MD
- HIV/AIDS
Comparison of treated versus untreated patients identified during acute infection found no significant difference in viral loads an estimated 36 months after infection.
- Reviewing:
- Desquilbet L et al., AIDS 2004 Dec 3; 18:2361-9.
- Related Searches: anti-retroviral agents, drug holiday, hiv, hiv infection syndrome, acute, viral load result
High Semen HIV Levels During Acute Infection May Shape Epidemic
- August 1, 2004
- Abigail Zuger, MD
- HIV/AIDS
During acute HIV infection, high semen levels of the virus make men "biologically hyperinfectious;" a sizeable fraction of sexual transmission of HIV may take place during this time.
- Reviewing:
- Pilcher CD et al., J Infect Dis 2004 May 15; 189:1785-92.
Untangling the Sequence of Events in Acute Infection
- November 1, 2003
- Deborah J. Cotton, MD, MPH
- HIV/AIDS
Researchers examined samples from blood donors with acute infection to determine which tests show what and when.
Risk for Vertical Postpartum HIV Transmission During Acute Infection
- August 24, 2009
- Sonia Nagy Chimienti, MD
- HIV/AIDS
In a retrospective case series of women who acquired HIV from postpartum blood transfusions, the absolute risk for transmitting HIV vertically through breast-feeding was 36%.
- Reviewing:
- Liang K et al., J Infect Dis 2009 Sep 1; 200:682. Lockman S and Creek T., J Infect Dis 2009 Sep 1; 200:667.
- Related Searches: breast feeding, hiv, hiv transmission, postpartum infection, vertical disease transmission
Is It Time to Start Treating Acute HIV Infection?
- August 15, 2011
- Charles B. Hicks, MD
- HIV/AIDS
Trial data presented at IAS 2011 demonstrate some virologic and immunologic benefit to starting antiretroviral therapy during acute HIV infection.
- Related Searches: anti-retroviral agents, cd4 count determination procedure, hiv, hiv infection, hiv infection syndrome, acute, spartac
HCV Transmission in HIV-Positive MSM — Sex, Not Just Drugs
- August 8, 2011
- Rajesh T. Gandhi, MD
- HIV/AIDS
High-risk sexual behavior is associated with HCV transmission among HIV-positive men who have sex with men.
- Reviewing:
- Centers for Disease Control and Prevention (CDC)., MMWR Morb Mortal Wkly Rep 2011 Jul 22; 60:945.
- Related Searches: acute hepatitis c, alanine aminotransferase increased, drug abuse methamphetamine, hepatitis c, hepatitis c antibody measurement, hepatitis c rna, hepatitis c virus, hiv, hiv infection, male homosexuality, syphilis and hiv
HCV Infection in HIV-Positive MSM
- February 28, 2011
- Rajesh T. Gandhi, MD
- HIV/AIDS
In HIV-positive men who have sex with men, HCV acquisition is not uncommon and is often due to sexual exposure.
- Reviewing:
- Tayor LE et al., Clin Infect Dis 2011 Jan 31;: Matthews GV et al., Clin Infect Dis 2011 Jan 31;: The European AIDS Treatment Network (NEAT) Acute Hepatitis C Infection Consensus Panel., AIDS 2011 Feb 20; 25:399.
- Related Searches: hepatitis c, hepatitis c virus, hiv, male homosexuality
Interpreting Positive HIV Test Results in Pregnant Women
- February 28, 2011
- Sonia Nagy Chimienti, MD
- HIV/AIDS
False-positive HIV test results are rare in the U.S., particularly among pregnant women.
- Reviewing:
- Wesolowski LG et al., PLoS ONE 2011 Jan 27; 6:e16538.
- Related Searches: enzyme immunoassay, false-positive results, hiv, hiv and pregnancy, hiv screen, pregnancy
Interim CDC Guidance on Pre-Exposure Prophylaxis for HIV Prevention in MSM Free
- February 14, 2011
- Raphael J. Landovitz, MD, MSc
- HIV/AIDS
In the wake of the iPrEx study, the CDC offers some general guiding principles for the implementation of pre-exposure prophylaxis.
- Reviewing:
- Centers for Disease Control and Prevention (CDC)., MMWR Morb Mortal Wkly Rep 2011 Jan 28; 60:65.
- Related Searches: chemoprevention, hiv prevention, hiv screen, iprex, male homosexuality, tenofovir/emtricitabine
More Support for Expanded HIV Screening and ART Access in the U.S.
- January 14, 2011
- Rochelle P. Walensky, MD, MPH
- HIV/AIDS
Expanding HIV screening and access to antiretroviral therapy is cost-effective, whether these strategies are implemented together or individually.
- Reviewing:
- Long EF et al., Ann Intern Med 2010 Dec 21; 153:778.
- Related Searches: anti-retroviral agents, cost effectiveness, health services accessibility, hiv screen, quality-adjusted life years
New HIV Test Approved
- June 28, 2010
- Charles B. Hicks, MD, and Paul E. Sax, MD
- HIV/AIDS
The test can detect both HIV antibodies and HIV p24 antigen, thus enabling diagnosis of acute as well as chronic infection.
- Related Searches: hiv, hiv 1 rna assay, hiv p24 antigen test, hiv screen, hiv-1 antibody assay, united states food and drug administration
Treating Acute Hepatitis C Virus Infection in HIV-Coinfected Patients
- May 24, 2010
- Sonia Nagy Chimienti, MD
- HIV/AIDS
Coinfected patients who have a rapid or early virologic response to HCV treatment are likely to have a sustained response.
- Reviewing:
- Vogel M et al., Antivir Ther 2010; 15:267.
- Related Searches: acute hepatitis c, hepatitis c, hepatitis c virus, hiv, peginterferon, ribavirin
Identifying Patients with Acute HIV Infection and Their Partners
- August 10, 2009
- Sonia Nagy Chimienti, MD
- HIV/AIDS
In North Carolina, a protocol for negative or indeterminate HIV-antibody results that involved nucleic acid amplification testing, confirmatory antibody testing, and follow-up interviews led to identification of newly infected partners of newly infected patients.
- Reviewing:
- Moore ZS et al., J Acquir Immune Defic Syndr 2009 Jun 26;:
- Related Searches: hiv, hiv screen, hiv-1 antibody assay, nucleic acid amplification tests, sexual partners
Stuck in the Middle Free
- July 27, 2009
- HIV/AIDS
A clinician sustains a needlestick from a patient who refuses HIV testing. An HIV physician, an attorney, and an ethicist weigh provide weigh in on how best to manage.
- Related Searches: hiv postexposure prophylaxis, hiv screen, needlestick injuries, refusal of consent
Which HIV Test Is Best in High-Incidence Groups?
- July 27, 2009
- Carlos del Rio, MD
- HIV/AIDS
In a study of specimens from Seattle-area MSM, a rapid antibody test detected HIV infection less well than did either enzyme immunoassay antibody testing or nucleic-acid amplification testing.
- Reviewing:
- Stekler JD et al., Clin Infect Dis 2009 Aug 1; 49:444.
- Related Searches: enzyme immunoassay, hiv, hiv screen, male homosexuality, nucleic acid amplification tests, oraquick rapid hiv-1 antibody test
HIV Testing — Targeting High-Risk Populations
- June 1, 2009
- Charles B. Hicks, MD
- HIV/AIDS
In an innovative program of bathhouse-based HIV testing, 4% of participants were found to be HIV-infected.
- Reviewing:
- Daskalakis D et al., Clin Infect Dis 2009 Jun 1; 48:1609.
- Related Searches: hiv, hiv screen, male homosexuality, rapid hiv test
What Happens When PEP or PrEP Fails?
- September 29, 2008
- Raphael J. Landovitz, MD
- HIV/AIDS
A case report provides at least some reassurance that failure of antiretroviral prophylaxis does not necessarily result in drug resistance.
- Reviewing:
- Prada N et al., J Acquir Immune Defic Syndr 2008 Sep 2;:
- Related Searches: anti-retroviral agents, drug resistance, emtricitabine, hiv, hiv postexposure prophylaxis, hiv prevention, tenofovir, tenofovir/emtricitabine
Continued Problems with Late HIV Diagnosis and New Problems with Testing Scale-Up
- March 10, 2008
- Carlos del Rio, MD
- HIV/AIDS
Several reports presented at the 15th Retrovirus Conference highlighted ongoing challenges with HIV testing.
- Related Searches: acquired immunodeficiency syndrome, anti-retroviral agents, hiv, hiv screen

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Search for Acute Infection in HIV/AIDS Clinical Care

Nucleic-Acid Amplification Testing Might Improve Detection of Acute Infection

Massive CD4+ T cell Depletion in Acute Infection

No Clear Benefit of Antiretroviral Therapy for Acute Infection: More Evidence

High Semen HIV Levels During Acute Infection May Shape Epidemic

Untangling the Sequence of Events in Acute Infection

Risk for Vertical Postpartum HIV Transmission During Acute Infection

Is It Time to Start Treating Acute HIV Infection?

HCV Transmission in HIV-Positive MSM — Sex, Not Just Drugs

HCV Infection in HIV-Positive MSM

Interpreting Positive HIV Test Results in Pregnant Women

Interim CDC Guidance on Pre-Exposure Prophylaxis for HIV Prevention in MSM Free

More Support for Expanded HIV Screening and ART Access in the U.S.

New HIV Test Approved

Treating Acute Hepatitis C Virus Infection in HIV-Coinfected Patients

Identifying Patients with Acute HIV Infection and Their Partners

Stuck in the Middle Free

Which HIV Test Is Best in High-Incidence Groups?

HIV Testing — Targeting High-Risk Populations

What Happens When PEP or PrEP Fails?

Continued Problems with Late HIV Diagnosis and New Problems with Testing Scale-Up

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