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Search for Adherence in HIV/AIDS Clinical Care
Physician-authored summaries on the latest research on adherence, editorials on adherence, and perspectives on adherence - drawn from the top medical journals.
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You searched for: adherence in HIV/AIDS
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An Adherence Intervention That Works — but with a Catch
- February 25, 2013
- Paul E. Sax, MD
- HIV/AIDS
Unfortunately, most practices won't have the resources to implement it.- Reviewing:
- Gross R et al., JAMA Intern Med 2013 Jan 28;: Bangsberg DR and Haberer JE., JAMA Intern Med 2013 Jan 28;:
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A Large Study Confirms Most of the Usual Adherence Predictors
- February 11, 2013
- Abigail Zuger, MD
- HIV/AIDS
Black race, residence in the U.S., and greater pill burden predicted poor adherence — or possibly just the willingness to admit it.- Reviewing:
- O'Connor JL et al., J Infect Dis 2013 Jan 31;:
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High Adherence Key to Success with Raltegravir-Based Regimens Free
- November 9, 2012
- Keith Henry, MD
- HIV/AIDS
Treatment interruptions and decreased adherence raised the risk for virologic failure with twice-daily raltegravir-based regimens.- Reviewing:
- Gras G et al., J Acquir Immune Defic Syndr 2012 Nov 1; 61:265.
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ART Adherence Lower Among Blacks Than Whites Free
- August 13, 2012
- Keith Henry, MD
- HIV/AIDS
The association persisted even after adjustment for demographics, depression, and substance use.- Reviewing:
- Simoni JM et al., J Acquir Immune Defic Syndr 2012 Aug 15; 60:466.
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One Pill Daily for HIV: Better Adherence, Better Health?
- March 19, 2012
- Abigail Zuger, MD
- HIV/AIDS
Patients on one pill daily seemed to stay healthier than those on more complicated regimens, but some questions remain.- Reviewing:
- Sax PE et al., PLoS ONE 2012 Feb; 7:e31591.
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Can Behavioral Interventions Improve HIV Treatment Adherence and Viral Control?
- February 28, 2011
- Salim S. Abdool Karim, MD, PhD
- HIV/AIDS
An intensive behavioral intervention improved treatment adherence and reduced the frequency of risky sex but had no effect on virologic suppression.- Reviewing:
- Kalichman SC et al., Am J Public Health 2011 Mar; 101:531.
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Text Messages Can Help Improve Adherence to ART
- February 18, 2011
- Carlos del Rio, MD
- HIV/AIDS
Sending your patients short text reminders every week may help improve their adherence to antiretroviral therapy.- Reviewing:
- Pop-Eleches C et al., AIDS 2011 Feb 10;:
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What's the Best Way to Measure ART Adherence?
- February 14, 2011
- Keith Henry, MD
- HIV/AIDS
The matter is neither simple nor settled.- Reviewing:
- McMahon JH et al., Clin Infect Dis 2011 Feb 15; 52:493.
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Adherence and Response to Darunavir vs. Lopinavir
- June 28, 2010
- Paul E. Sax, MD
- HIV/AIDS
Rates of virologic suppression were similar between the two drugs in patients with >95% adherence — but darunavir outperformed lopinavir in those with suboptimal adherence.- Reviewing:
- Nelson M et al., J Antimicrob Chemother 2010 Jul; 65:1505.
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What Influences Long-Term Adherence to Antiretroviral Therapy?
- June 14, 2010
- Keith Henry, MD
- HIV/AIDS
In addition to the usual suspects (such as age and substance use), personal life events and changes in the provider/patient relationship also influenced adherence.- Reviewing:
- Glass TR et al., J Acquir Immune Defic Syndr 2010 Jun 1; 54:197.
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Good News Regarding Long-Term Adherence to Antiretroviral Therapy Free
- May 24, 2010
- Keith Henry, MD
- HIV/AIDS
In a London-based cohort of HIV-infected patients with universal access to ART, adherence rates were high and continued to improve with longer durations of therapy.- Reviewing:
- Cambiano V et al., AIDS 2010 May 15; 24:1153.
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The Number of Doses Matters in Adherence
- February 9, 2009
- Paulina Rebolledo, MD, MSc, and Carlos del Rio, MD
- HIV/AIDS
A meta-analysis of 11 randomized, controlled trials suggests that adherence is better with once-daily than with twice-daily regimens.- Reviewing:
- Parienti J-J et al., Clin Infect Dis 2009 Feb 15; 48:484.
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Antidepressants, ART Adherence, and HIV Outcomes
- February 25, 2008
- Valerie Stone, MD, MPH
- HIV/AIDS
In a retrospective study, treating depression seemed to attenuate, or even eliminate, the negative effects of this condition on ART adherence and HIV outcomes.- Reviewing:
- Horberg MA et al., J Acquir Immune Defic Syndr 2007 Dec 13;:
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Virologic Failure: The Roles of Race, Adherence, and Quality of Life
- December 3, 2007
- Carlos del Rio, MD
- HIV/AIDS
In ACTG 5095, nonadherence to efavirenz-containing regimens increased risk for virologic failure in blacks but not in whites.- Reviewing:
- Schackman BR et al., J Acquir Immune Defic Syndr 2007 Dec 15; 46:547. Pence BW et al., J Acquir Immune Defic Syndr 2007 Nov 8;:
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How Much Adherence Is Enough? Free
- July 2, 2007
- Carlos del Rio, MD
- HIV/AIDS
In two new studies, moderate adherence to an NNRTI- or boosted-PI–based regimen often led to sustained virologic suppression.- Reviewing:
- Nachega JB et al., Ann Intern Med 2007 Apr 17; 146:564-73. Shuter J et al., J Acquir Immune Defic Syndr 2007 May 1; 45:4-8.
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Do NNRTI-Based Regimens Work at <95% Adherence?
- October 23, 2006
- Keith Henry, MD
- HIV/AIDS
Among homeless HIV-infected patients, viral suppression was more likely to be achieved with NNRTI-based therapy than with unboosted PI-based therapy, even when adherence was <95%.- Reviewing:
- Bangsberg DR., Clin Infect Dis 2006 Oct 1; 43:939-41. Gulick RM., Clin Infect Dis 2006 Oct 1; 43:942-4.
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Adherence to Antiretroviral Therapy: Africa vs. North America Free
- September 1, 2006
- Keith Henry, MD
- HIV/AIDS
A meta-analysis of adherence studies yielded a pooled estimate of 77% adequate adherence in Africa versus 55% in North America.- Reviewing:
- Mills EJ et al., JAMA 2006 Aug 9; 296:679-90.
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Case Management Found to Improve Adherence and CD4-Cell Counts
- July 17, 2006
- Keith Henry, MD
- HIV/AIDS
In an observational study of HIV-infected people with unstable housing, increased use of case management was linked to greater medication adherence and increased CD4-cell counts.- Reviewing:
- Kushel MB et al., Clin Infect Dis 2006 Jul 15; 43:234-42.
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Do Adherence Interventions Make a Difference?
- May 31, 2006
- Carlos del Rio, MD
- HIV/AIDS
Two studies shed light on the potential effectiveness of adherence interventions in high-risk populations.- Reviewing:
- Wohl AR et al., Clin Infect Dis 2006 Jun 1; 42:1619-27. Lucas GM et al., Clin Infect Dis 2006 Jun 1; 42:1628-35. Flanigan TP and Mitty JA., Clin Infect Dis 2006 Jun 1; 42:1636-8.
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Lopinavir/Ritonavir Forgives Poor Adherence
- July 13, 2005
- Abigail Zuger, MD
- HIV/AIDS
Less than perfectly adherent patients had better virologic suppression with a regimen containing lopinavir/r than one containing nelfinavir.- Reviewing:
- King MS et al., J Infect Dis 2005 Jun 15; 191:2046-52.
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