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Adherence
Physician-authored summaries on the latest research on adherence, editorials on adherence, and perspectives on adherence - drawn from the top medical journals.
You searched for: adherence Items 1 to 20 of 216 results
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How Much Adherence Is Enough?Free!
- July 2, 2007
- Carlos del Rio, MD
In two new studies, moderate adherence to an NNRTI- or boosted-PI–based regimen often led to sustained virologic suppression.- Covering:
- Nachega JB et al., Ann Intern Med 2007 Apr 17; 146:564-73.
- Shuter J et al., J Acquir Immune Defic Syndr 2007 May 1; 45:4-8.
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Do NNRTI-Based Regimens Work at <95% Adherence?
- October 23, 2006
- Keith Henry, MD
Among homeless HIV-infected patients, viral suppression was more likely to be achieved with NNRTI-based therapy than with unboosted PI-based therapy, even when adherence was <95%.- Covering:
- Bangsberg DR., Clin Infect Dis 2006 Oct 1; 43:939-41.
- Gulick RM., Clin Infect Dis 2006 Oct 1; 43:942-4.
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Adherence to Antiretroviral Therapy: Africa vs. North AmericaFree!
- September 1, 2006
- Keith Henry, MD
A meta-analysis of adherence studies yielded a pooled estimate of 77% adequate adherence in Africa versus 55% in North America.- Covering:
- Mills EJ et al., JAMA 2006 Aug 9; 296:679-90.
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Case Management Found to Improve Adherence and CD4-Cell Counts
- July 17, 2006
- Keith Henry, MD
In an observational study of HIV-infected people with unstable housing, increased use of case management was linked to greater medication adherence and increased CD4-cell counts.- Covering:
- Kushel MB et al., Clin Infect Dis 2006 Jul 15; 43:234-42.
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Do Adherence Interventions Make a Difference?
- May 31, 2006
- Carlos del Rio, MD
Two studies shed light on the potential effectiveness of adherence interventions in high-risk populations.- Covering:
- Wohl AR et al., Clin Infect Dis 2006 Jun 1; 42:1619-27.
- Lucas GM et al., Clin Infect Dis 2006 Jun 1; 42:1628-35.
- Flanigan TP and Mitty JA., Clin Infect Dis 2006 Jun 1; 42:1636-8.
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Virologic Failure: The Roles of Race, Adherence, and Quality of Life
- December 3, 2007
- Carlos del Rio, MD
In ACTG 5095, nonadherence to efavirenz-containing regimens increased risk for virologic failure in blacks but not in whites.- Covering:
- Schackman BR et al., J Acquir Immune Defic Syndr 2007 Dec 15; 46:547.
- Pence BW et al., J Acquir Immune Defic Syndr 2007 Nov 8;:
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Lopinavir/Ritonavir Forgives Poor Adherence
- July 13, 2005
- Abigail Zuger, MD
Less than perfectly adherent patients had better virologic suppression with a regimen containing lopinavir/r than one containing nelfinavir.- Covering:
- King MS et al., J Infect Dis 2005 Jun 15; 191:2046-52.
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Antidepressants, ART Adherence, and HIV Outcomes
- February 25, 2008
- Valerie Stone, MD, MPH
In a retrospective study, treating depression seemed to attenuate, or even eliminate, the negative effects of this condition on ART adherence and HIV outcomes.- Covering:
- Horberg MA et al., J Acquir Immune Defic Syndr 2007 Dec 13;:
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Does High Baseline Viral Load Predict Treatment Outcomes?
- June 28, 2006
- Paul E. Sax, MD
In patients with baseline CD4 counts ≥200 cells/mm3, baseline viral load did not predict survival, so long as adherence to antiretroviral therapy was 95% or better.- Covering:
- Wood E et al., AIDS 2006 May 12; 20:1117-23.
- Mussini C., AIDS 2006 May 12; 20:1197-8.
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Are Adherence Interventions Cost-Effective?
- May 1, 2004
- G. Sonia Nagy, MD
This mathematical model suggests that even only slightly effective adherence interventions are likely to be cost-effective in populations at the greatest risk of disease progression.- Covering:
- Goldie SJ et al., Am J Med 2003 Dec 1; 115:632-41.
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Check Adherence before Switching Drugs
- March 1, 2000
- Abigail Zuger, MD
Two studies suggest that when a regimen begins to fail, low drug levels or poor adherence, rather than drug resistance, may be responsible.- Covering:
- Descamps D et al., JAMA 2000 Jan 12; 283:
205 211 . - Havlir D et al., JAMA 2000 Jan 12; 283:
229 234 . - Markowitz M., JAMA 2000 Jan 12; 282:
250 251 .
- Descamps D et al., JAMA 2000 Jan 12; 283:
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Patient Adherence and Response to Therapy
- August 1, 1999
- Paul E. Sax, MD
Patient self-report of adherence strongly predicts viral load and CD4 response to antiretroviral therapy; providers once again make poor estimates of their patients' behavior.- Covering:
- Haubrich RH et al., AIDS 1999 Jun 18; 13:
1099 1107 .
- Haubrich RH et al., AIDS 1999 Jun 18; 13:
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High Baseline Viral Loads Predict Virologic Failure
- April 27, 2005
- Paul E. Sax, MD
In an analysis that controlled for medication adherence, a high baseline viral load was strongly associated with failure to achieve virologic suppression.- Covering:
- Wood E et al., J Acquir Immune Defic Syndr 2005 Mar 1; 38:289-95.
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Adherence By Any Measure Still Matters
- July 1, 2001
- Abigail Zuger, MD
No single method of measuring adherence seems adequate for accurately assessing this important variable. -
All About Adherence
- February 1, 2001
Carmen B. has been on and off HIV medications and has moved in and out of care several times. Her adherence to most of her regimens has been intermittent. In August 2000, she was lost to follow-up again. She reappeared in October 2000, stating that she had a new social worker, new support groups, a new therapist, and was in a much better life-situation; she convincingly argued that she was prepared to restart antiretrovirals. Her viral load was 92,500 copies/ml and her CD4 count was 138 cells/mm3 (17%). She started AZT + 3TC + ritonavir + indinavir. Two weeks after beginning her new regimen, she appeared happy and noted 100% adherence and no side effects. An indinavir level, drawn 2 hours after her last reported dose, returned at less than 0.025 µg/ml, below the limits of detection. -
Measuring HIV Treatment Adherence in Clinical Practice
- August 1, 1998
- Frederick M. Hecht, MD
Adherence to HIV treatment is a key factor in determining whether our patients develop undetectable HIV viremia or drug-resistant HIV. But how do we determine . . . -
Delivery of Postexposure Prophylaxis in Amsterdam
- May 11, 2005
- Sigal Yawetz, MD
A new protocol for delivering postexposure prophylaxis resulted in relatively high rates of contact tracing, timely treatment, and adherence.- Covering:
- Sonder GJB et al., BMJ 2005 Apr 9; 330:825-9.
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Expanded HIV Treatment in Resource-Poor CountriesFree!
- December 29, 2006
Initial concerns that antiretroviral therapy would be less effective in resource-poor settings ― or that patients there would be less adherent ― appear to be unfounded. -
Report from ICAAC, 2006
- October 30, 2006
ICAAC did not generate much substantial HIV news in 2006, but a few presentations were noteworthy. -
A Patient with Multiple Resistance Mutations and a History of Nonadherence
- October 16, 2006
Two experts discuss the pharmacologic and psychological challenges of managing this patient’s HIV.
You searched for: adherence Items 1 to 20 of 216 results