Search for Adherence in HIV/AIDS Clinical Care

Physician-authored summaries on the latest research on adherence, editorials on adherence, and perspectives on adherence - drawn from the top medical journals.

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The Number of Doses Matters in Adherence
- February 9, 2009
- Paulina Rebolledo, MD, MSc, and Carlos del Rio, MD
- HIV/AIDS
A meta-analysis of 11 randomized, controlled trials suggests that adherence is better with once-daily than with twice-daily regimens.
- Reviewing:
- Parienti J-J et al., Clin Infect Dis 2009 Feb 15; 48:484.
- Related Searches: anti-retroviral agents, hiv, patient compliance
Antidepressants, ART Adherence, and HIV Outcomes
- February 25, 2008
- Valerie Stone, MD, MPH
- HIV/AIDS
In a retrospective study, treating depression seemed to attenuate, or even eliminate, the negative effects of this condition on ART adherence and HIV outcomes.
- Reviewing:
- Horberg MA et al., J Acquir Immune Defic Syndr 2007 Dec 13;:
- Related Searches: acquired immunodeficiency syndrome, antidepressive agents, anti-retroviral agents, depression, hiv, patient compliance, selective serotonin re-uptake inhibitor
Virologic Failure: The Roles of Race, Adherence, and Quality of Life
- December 3, 2007
- Carlos del Rio, MD
- HIV/AIDS
In ACTG 5095, nonadherence to efavirenz-containing regimens increased risk for virologic failure in blacks but not in whites.
- Reviewing:
- Schackman BR et al., J Acquir Immune Defic Syndr 2007 Dec 15; 46:547. Pence BW et al., J Acquir Immune Defic Syndr 2007 Nov 8;:
- Related Searches: acquired immunodeficiency syndrome, anti-retroviral agents, blacks, efavirenz, ethnic group, hiv, patient compliance, quality of life, racial differences, whites
How Much Adherence Is Enough? Free
- July 2, 2007
- Carlos del Rio, MD
- HIV/AIDS
In two new studies, moderate adherence to an NNRTI- or boosted-PI–based regimen often led to sustained virologic suppression.
- Reviewing:
- Nachega JB et al., Ann Intern Med 2007 Apr 17; 146:564-73. Shuter J et al., J Acquir Immune Defic Syndr 2007 May 1; 45:4-8.
- Related Searches: anti-retroviral agents, efavirenz, hiv, hiv protease inhibitors, lopinavir/ritonavir, nevirapine, non-nucleoside reverse transcriptase inhibitors, patient compliance
Do NNRTI-Based Regimens Work at <95% Adherence?
- October 23, 2006
- Keith Henry, MD
- HIV/AIDS
Among homeless HIV-infected patients, viral suppression was more likely to be achieved with NNRTI-based therapy than with unboosted PI-based therapy, even when adherence was <95%.
- Reviewing:
- Bangsberg DR., Clin Infect Dis 2006 Oct 1; 43:939-41. Gulick RM., Clin Infect Dis 2006 Oct 1; 43:942-4.
- Related Searches: anti-retroviral agents, efavirenz, hiv, indinavir, nelfinavir, nevirapine, non-nucleoside reverse transcriptase inhibitors, patient compliance, protease inhibitor, reverse transcriptase inhibitors
Adherence to Antiretroviral Therapy: Africa vs. North America Free
- September 1, 2006
- Keith Henry, MD
- HIV/AIDS
A meta-analysis of adherence studies yielded a pooled estimate of 77% adequate adherence in Africa versus 55% in North America.
- Reviewing:
- Mills EJ et al., JAMA 2006 Aug 9; 296:679-90.
- Related Searches: africa, anti-retroviral agents, hiv, north america, patient compliance
Case Management Found to Improve Adherence and CD4-Cell Counts
- July 17, 2006
- Keith Henry, MD
- HIV/AIDS
In an observational study of HIV-infected people with unstable housing, increased use of case management was linked to greater medication adherence and increased CD4-cell counts.
- Reviewing:
- Kushel MB et al., Clin Infect Dis 2006 Jul 15; 43:234-42.
- Related Searches: case management, cd4 count determination procedure, hiv, patient compliance
Do Adherence Interventions Make a Difference?
- May 31, 2006
- Carlos del Rio, MD
- HIV/AIDS
Two studies shed light on the potential effectiveness of adherence interventions in high-risk populations.
- Reviewing:
- Wohl AR et al., Clin Infect Dis 2006 Jun 1; 42:1619-27. Lucas GM et al., Clin Infect Dis 2006 Jun 1; 42:1628-35. Flanigan TP and Mitty JA., Clin Infect Dis 2006 Jun 1; 42:1636-8.
- Related Searches: anti-retroviral agents, case management, hiv, patient compliance
Lopinavir/Ritonavir Forgives Poor Adherence
- July 13, 2005
- Abigail Zuger, MD
- HIV/AIDS
Less than perfectly adherent patients had better virologic suppression with a regimen containing lopinavir/r than one containing nelfinavir.
- Reviewing:
- King MS et al., J Infect Dis 2005 Jun 15; 191:2046-52.
- Related Searches: anti-retroviral agents, drug resistance, hiv, lamivudine, lopinavir, patient compliance, ritonavir, stavudine
Diminished CD4-Cell Recovery in Older Patients Despite Good Adherence
- September 22, 2008
- Keith Henry, MD
- HIV/AIDS
A small retrospective study highlights the importance of detecting HIV early in older individuals.
- Reviewing:
- Brañas F et al., Am J Med 2008 Sep; 121:820.
- Related Searches: antiretroviral therapy, highly active, cd4 count determination procedure, hiv, viral load result
Pharmacy Records: A Substitute for Viral-Load Monitoring in Resource-Poor Settings? Free
- June 30, 2008
- Abigail Zuger, MD
- HIV/AIDS
Low adherence may predict virologic failure better than do changes in CD4-cell count.
- Reviewing:
- Bisson GP et al., PLoS Med 2008 May 20; 5:e109.
- Related Searches: anti-retroviral agents, hiv, patient compliance
Does High Baseline Viral Load Predict Treatment Outcomes?
- June 28, 2006
- Paul E. Sax, MD
- HIV/AIDS
In patients with baseline CD4 counts ≥200 cells/mm3, baseline viral load did not predict survival, so long as adherence to antiretroviral therapy was 95% or better.
- Reviewing:
- Wood E et al., AIDS 2006 May 12; 20:1117-23. Mussini C., AIDS 2006 May 12; 20:1197-8.
- Related Searches: anti-retroviral agents, cd4 count determination procedure, hiv, patient compliance, viral load result
Are Adherence Interventions Cost-Effective?
- May 1, 2004
- G. Sonia Nagy, MD
- HIV/AIDS
This mathematical model suggests that even only slightly effective adherence interventions are likely to be cost-effective in populations at the greatest risk of disease progression.
- Reviewing:
- Goldie SJ et al., Am J Med 2003 Dec 1; 115:632-41.
Check Adherence before Switching Drugs
- March 1, 2000
- Abigail Zuger, MD
- HIV/AIDS
Two studies suggest that when a regimen begins to fail, low drug levels or poor adherence, rather than drug resistance, may be responsible.
- Reviewing:
- Descamps D et al., JAMA 2000 Jan 12; 283:205211. Havlir D et al., JAMA 2000 Jan 12; 283:229234. Markowitz M., JAMA 2000 Jan 12; 282:250251.
Patient Adherence and Response to Therapy
- August 1, 1999
- Paul E. Sax, MD
- HIV/AIDS
Patient self-report of adherence strongly predicts viral load and CD4 response to antiretroviral therapy; providers once again make poor estimates of their patients' behavior.
- Reviewing:
- Haubrich RH et al., AIDS 1999 Jun 18; 13:10991107.
When Your Patient Is Too Busy to Take Meds Free
- May 18, 2009
- HIV/AIDS
Two experts describe how they would encourage adherence in an AIDS patient already overburdened with work and family responsibilities.
- Related Searches: anti-retroviral agents, hiv, noncompliance with treatment, patient compliance
Outcomes of ART in South Africa Are Similar to Those in Switzerland Free
- August 18, 2008
- Gerald H. Friedland, MD
- HIV/AIDS
New study results should make it clear to any remaining doubters that antiretroviral therapy can be provided successfully in resource-limited settings in sub-Saharan Africa.
- Reviewing:
- Keiser O et al., PLoS Med 2008 Jul 8; 5:e148.
- Related Searches: anti-retroviral agents, hiv, patient compliance, public health practice, south africa, switzerland
Expanded HIV Treatment in Resource-Poor Countries Free
- December 29, 2006
- HIV/AIDS
Initial concerns that antiretroviral therapy would be less effective in resource-poor settings ― or that patients there would be less adherent ― appear to be unfounded.
- Related Searches: anti-retroviral agents, hiv, lamivudine, nevirapine, patient compliance, poverty, stavudine
Report from ICAAC, 2006
- October 30, 2006
- HIV/AIDS
ICAAC did not generate much substantial HIV news in 2006, but a few presentations were noteworthy.
- Related Searches: atazanavir, efavirenz, fosamprenavir, hiv, ICAAC, integrase inhibitors, mk-0518, patient compliance, ritonavir
A Patient with Multiple Resistance Mutations and a History of Nonadherence
- October 16, 2006
- HIV/AIDS
Two experts discuss the pharmacologic and psychological challenges of managing this patient’s HIV.
- Related Searches: anti-retroviral agents, drug resistance, hiv, patient compliance, reverse transcriptase inhibitors

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Items 1 to 20 of 258 results

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Search for Adherence in HIV/AIDS Clinical Care

The Number of Doses Matters in Adherence

Antidepressants, ART Adherence, and HIV Outcomes

Virologic Failure: The Roles of Race, Adherence, and Quality of Life

How Much Adherence Is Enough? Free

Do NNRTI-Based Regimens Work at <95% Adherence?

Adherence to Antiretroviral Therapy: Africa vs. North America Free

Case Management Found to Improve Adherence and CD4-Cell Counts

Do Adherence Interventions Make a Difference?

Lopinavir/Ritonavir Forgives Poor Adherence

Diminished CD4-Cell Recovery in Older Patients Despite Good Adherence

Pharmacy Records: A Substitute for Viral-Load Monitoring in Resource-Poor Settings? Free

Does High Baseline Viral Load Predict Treatment Outcomes?

Are Adherence Interventions Cost-Effective?

Check Adherence before Switching Drugs

Patient Adherence and Response to Therapy

When Your Patient Is Too Busy to Take Meds Free

Outcomes of ART in South Africa Are Similar to Those in Switzerland Free

Expanded HIV Treatment in Resource-Poor Countries Free

Report from ICAAC, 2006

A Patient with Multiple Resistance Mutations and a History of Nonadherence

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