Search for Initial Therapy in HIV/AIDS Clinical Care

Physician-authored summaries on the latest research on initial therapy, editorials on initial therapy, and perspectives on initial therapy - drawn from the top medical journals.

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You searched for: initial therapy in HIV/AIDS

Report from the 2008 Joint ICAAC/IDSA Meeting Free
- November 10, 2008
- HIV/AIDS
The most important HIV-related findings from this year’s meeting
- Related Searches: abacavir/lamivudine, anti-retroviral agents, artemis, atazanavir, bevirimat, castle, darunavir, drug resistance, viral, efavirenz, hiv, hiv, ccr5-tropic, lopinavir/ritonavir, maraviroc, MERIT, mortality, raltegravir
Early Virologic Failure with Tenofovir/FTC + Nevirapine as Initial Therapy Free
- April 14, 2008
- Paul E. Sax, MD
- HIV/AIDS
Investigators stopped a clinical study when three of seven patients receiving tenofovir/FTC + nevirapine experienced early virologic rebound; each had evidence of multiclass viral resistance.
- Reviewing:
- Lapadula G et al., Clin Infect Dis 2008 Apr 1; 46:1127.
- Related Searches: anti-retroviral agents, atazanavir, hiv, nevirapine, tenofovir/emtricitabine
Efavirenz vs. Lopinavir/Ritonavir for Initial Therapy
- February 1, 2005
- Keith Henry, MD
- HIV/AIDS
In a small nonrandomized study, open-label treatment with efavirenz and lopinavir/ritonavir resulted in similar peak CD4 counts and rates of virologic suppression; the efavirenz group had a higher CD4 count and a lower rate of AIDS at baseline.
- Reviewing:
- Manfredi R et al., AIDS 2004 Nov 19; 18:2331-3.
- Related Searches: acquired immunodeficiency syndrome, cd4 count determination procedure, efavirenz, hiv, lopinavir/ritonavir
Can Lopinavir/Ritonavir Be Dosed Once-Daily in Initial Therapy?
- March 1, 2004
- Bruce Soloway, MD
- HIV/AIDS
A small study suggests that once-daily and twice-daily lopinavir/ritonavir administration produce comparable clinical outcomes in treatment-naive patients, although other questions about once-daily dosing remain unanswered.
- Reviewing:
- Eron JJ et al., J Infect Dis 2004 Jan 15; 189:265-72.
Maraviroc in Treatment-Experienced and Treatment-Naive Patients Free
- September 10, 2007
- Charles B. Hicks, MD
- HIV/AIDS
Data presented at the 4th IAS Conference confirm the value of maraviroc for treatment-experienced patients, but its role in treatment-naive patients remains uncertain.
- Related Searches: anti-retroviral agents, chemokine (c-c motif) receptor 5, efavirenz, hiv, international aids conference, maraviroc, MERIT, MOTIVATE
Standard Triple-Drug Regimens Remain the Best for Initial Therapy Free
- December 29, 2006
- HIV/AIDS
Efavirenz-based regimens appear to be particularly effective.
- Related Searches: abacavir/lamivudine, anti-retroviral agents, efavirenz, fosamprenavir, hiv, lopinavir, lopinavir/ritonavir, protease inhibitor, reverse transcriptase inhibitors, ritonavir
NNRTIs More Durable Than PIs as Initial Therapy
- December 1, 2004
- Keith Henry, MD
- HIV/AIDS
In this prospective observational study, initial NNRTI-based combination therapy led to fewer regimen changes than did initial PI-based combination therapy.
- Reviewing:
- Klein MB et al. , AIDS 2004 Sep 24; 18:1895-904.
Abacavir as Initial Therapy and as a Once-Daily Drug
- November 1, 2003
- Paul E. Sax, MD
- HIV/AIDS
Preliminary results from two industry-sponsored studies suggested that abacavir -- currently used most commonly in treatment-experienced patients -- could be used in combination with 3TC and efavirenz as part of an initial antiretroviral regimen.
NNRTIs Best PIs . . . Again Free
- January 8, 2007
- Paul E. Sax, MD
- HIV/AIDS
In a large randomized trial of treatment-naive patients, the most virologically active strategy was two NRTIs plus an NNRTI; a triple-class strategy yielded greater toxicity but not greater efficacy.
- Reviewing:
- MacArthur RD et al., Lancet 2006 Dec 16; 368:2125-35. Abgrall S., Lancet 2006 Dec 16; 368:2107-9.
- Related Searches: anti-retroviral agents, efavirenz, hiv, nelfinavir, nevirapine, reverse transcriptase inhibitors
ACTG 384 -- Complicated, but Worth the Work
- January 1, 2004
- Paul E. Sax, MD
- HIV/AIDS
In this large, multicenter study comparing 6 different initial treatment strategies, AZT + 3TC + efavirenz emerged clearly superior to the other 5 combinations, including 4-drug triple-class regimens.
- Reviewing:
- Robbins GK et al., N Engl J Med 2003 Dec 11; 349:2293-303. Shafer RW et al., N Engl J Med 2003 Dec 11; 349:2304-15. Skolnik PR et al., N Engl J Med 2003 Dec 11; 349:2351-2.
Ritonavir-Boosted Saquinavir Is Comparable to Lopinavir/r in Treatment-Naive Patients
- May 4, 2009
- Paul E. Sax, MD
- HIV/AIDS
Ritonavir-boosted saquinavir was noninferior to lopinavir/r in an international trial but currently offers few advantages over other PIs.
- Reviewing:
- Walmsley S et al., J Acquir Immune Defic Syndr 2009 Apr 1; 50:367.
- Related Searches: hiv, hiv protease inhibitors, lopinavir/ritonavir, ritonavir, saquinavir
Investigational Pharmacologic Boosters
- March 9, 2009
- Charles B. Hicks, MD
- HIV/AIDS
Two promising alternatives to ritonavir were described at this year’s Retrovirus Conference.
- Related Searches: anti-retroviral agents, drug potentiation, gs-9350, hiv, hiv protease inhibitors, ritonavir, spi-452
Is Immune Reconstitution As Good the Second Time Around?
- November 24, 2008
- Helmut Albrecht, MD
- HIV/AIDS
In the majority of patients studied, resuming ART after treatment interruption resulted in good virologic control and early CD4-cell response, although CD4-cell increases were not as robust as during initial therapy.
- Reviewing:
- Touloumi G et al., J Acquir Immune Defic Syndr 2008 Nov 4;:
- Related Searches: anti-retroviral agents, antiretroviral therapy, highly active, CASCADE, cd4 positive t-lymphocytes, drug holiday, hiv, viral load result
The Latest Studies in Treatment-Naive Patients
- September 15, 2008
- Judith Feinberg, MD
- HIV/AIDS
Trials described at the 2008 International AIDS Conference highlighted possible new options for initial therapy but also raised questions about abacavir/3TC as an NRTI backbone.
- Related Searches: abacavir/lamivudine, anti-retroviral agents, efavirenz, hiv, raltegravir , rilpivirine, tenofovir/emtricitabine
When First Regimens Fail, Resistance Patterns Vary
- September 11, 2008
- Abigail Zuger, MD
- HIV/AIDS
Genotypic drug resistance is widespread following failure of initial therapy with NNRTIs but not with boosted PIs.
- Reviewing:
- Gupta R et al., Clin Infect Dis 2008 Sep 1; 47:712. Campbell TB., Clin Infect Dis 2008 Sep 1; 47:723.
- Related Searches: anti-retroviral agents, drug resistance, viral, genotype determination, hiv protease inhibitors, non-nucleoside reverse transcriptase inhibitors
Ritonavir-Boosted Atazanavir in Treatment-Naive Patients Free
- August 25, 2008
- Paul E. Sax, MD
- HIV/AIDS
Ritonavir-boosted atazanavir yielded rates of virologic suppression similar to those of lopinavir/r and was also associated with lower rates of gastrointestinal toxicity and lipid elevations.
- Reviewing:
- Molina J-M et al., Lancet 2008 Aug 23; 372:646.
- Related Searches: anti-retroviral agents, atazanavir, castle, gastrointestinal toxicity, hiv, lipids, lopinavir/ritonavir, ritonavir
Durability of Initial Antiretroviral Regimens in the Swiss HIV Cohort
- June 30, 2008
- Charles B. Hicks, MD
- HIV/AIDS
ART success rates have improved over time — currently, more than 90% of patients achieve viral suppression at 1 year — but switching because of intolerance remains common.
- Reviewing:
- Vo TTN et al., J Infect Dis 2008 Jun 15; 197:1685.
- Related Searches: acquired immunodeficiency syndrome, anti-retroviral agents, hiv, swiss hiv cohort study
DHHS Treatment Guidelines Tweaked Again Free
- February 11, 2008
- Abigail Zuger, MD
- HIV/AIDS
Specific drug recommendations for initial antiretroviral therapy have changed in this latest set of guidelines.
- Reviewing:
- Panel on Antiretroviral Guidelines for Adults and Adolescents., 2008 Jan 29;:
- Related Searches: anti-retroviral agents, guidelines, hiv, non-nucleoside reverse transcriptase inhibitors, protease inhibitor, reverse transcriptase inhibitors, tuberculosis and hiv, united states dept. of health and human services
Revised Package Insert for Atazanavir Free
- January 28, 2008
- Paul E. Sax, MD
- HIV/AIDS
The insert includes new information on administering the drug with acid-reducing therapies and on appropriate dosing in patients with renal failure.
- Related Searches: anti-retroviral agents, atazanavir, gastric acid suppression , histamine h2 antagonists, hiv, kidney failure, proton pump inhibitors, tenofovir
Top HIV/AIDS Stories of 2007 Free
- December 28, 2007
- Paul E. Sax, MD
- HIV/AIDS
A perspective on the year’s most important stories in HIV medicine
- Related Searches: abacavir, acquired immunodeficiency syndrome, aids vaccines, antiretroviral therapy, highly active, antiviral agents, darunavir, elvitegravir , etravirine, hiv, hiv integrase inhibitors, hiv prevention, hiv screen, lopinavir, male circumcision, maraviroc, multidrug-resistant hiv, raltegravir

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Search for Initial Therapy in HIV/AIDS Clinical Care

Report from the 2008 Joint ICAAC/IDSA Meeting Free

Early Virologic Failure with Tenofovir/FTC + Nevirapine as Initial Therapy Free

Efavirenz vs. Lopinavir/Ritonavir for Initial Therapy

Can Lopinavir/Ritonavir Be Dosed Once-Daily in Initial Therapy?

Maraviroc in Treatment-Experienced and Treatment-Naive Patients Free

Standard Triple-Drug Regimens Remain the Best for Initial Therapy Free

NNRTIs More Durable Than PIs as Initial Therapy

Abacavir as Initial Therapy and as a Once-Daily Drug

NNRTIs Best PIs . . . Again Free

ACTG 384 -- Complicated, but Worth the Work

Ritonavir-Boosted Saquinavir Is Comparable to Lopinavir/r in Treatment-Naive Patients

Investigational Pharmacologic Boosters

Is Immune Reconstitution As Good the Second Time Around?

The Latest Studies in Treatment-Naive Patients

When First Regimens Fail, Resistance Patterns Vary

Ritonavir-Boosted Atazanavir in Treatment-Naive Patients Free

Durability of Initial Antiretroviral Regimens in the Swiss HIV Cohort

DHHS Treatment Guidelines Tweaked Again Free

Revised Package Insert for Atazanavir Free

Top HIV/AIDS Stories of 2007 Free

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