Antiretroviral PrEP for Injection-Drug Users?
SUMMARY AND COMMENT
In a randomized, controlled trial involving injection-drug users in Thailand, tenofovir reduced the risk for HIV infection.
Reviewing:
Choopanya K et al., Lancet 2013 Jun 13; 381:2083
CMV Viremia in HIV-Infected Patients in Thailand
SUMMARY AND COMMENT
In a retrospective study of patients starting ART at CD4 counts <200 cells/mm3 , cytomegalovirus viremia was independently associated with increased 2-year mortality.
Reviewing:
Durier N et al., Clin Infect Dis 2013 Jul 1; 57:147
ART Is Associated with Regression of HPV-Related Cervical Dysplasia in HIV-Coinfected Women
SUMMARY AND COMMENT
Antiretroviral therapy increased the likelihood of human papillomavirus clearance.
Reviewing:
Blitz S et al., J Infect Dis 2013 May 24
Apparent Lack of Occult HIV infection Among Cancer Patients in the U.S.
SUMMARY AND COMMENT
Testing of patients at three academic cancer centers in the U.S. did not yield a single case of undiagnosed HIV infection.
Reviewing:
Shrestha S et al., AIDS Res Hum Retroviruses 2013 Jun; 29:887
PrEP Works in Injection-Drug Users — CDC Offers "Guidance"
FEATURE
New CDC guidance on PrEP for injection-drug users is a welcome addition to the HIV prevention effort, says Dr. Paul Sax in his HIV and ID Observations blog .
Syphilis Responds to a Single Dose of Benzathine Penicillin
SUMMARY AND COMMENT
Data from two large cohorts in Africa suggest that extra injections are unnecessary for HIV-coinfected patients.
Reviewing:
Dionne-Odom J et al., Clin Infect Dis 2013 Jun 15; 56:1829
Resisting Drug Resistance in Resource-Constrained Settings
SUMMARY AND COMMENT
Improving access to virologic monitoring in such settings is essential to maximizing HIV treatment outcomes.
Reviewing:
Hosseinipour MC et al., J Infect Dis 2013 Jun 15; 207:S49
ID Learning Unit — Aminoglycosides
FEATURE
Aminoglycoside prescribing has rapidly and progressively declined, says Dr. Paul Sax in his blog HIV and ID Observations , but these antibiotics still have their place.
B-Cell Lymphomas in HIV/HCV-Coinfected Patients
SUMMARY AND COMMENT
The histology of lymphomas in this population differs from that seen in HIV-monoinfected patients, suggesting a novel mechanism of lymphomagenesis.
Reviewing:
Terrier B et al., J Acquir Immune Defic Syndr 2013 Jun 1; 63:249
HIV/Syphilis Among MSM in China
SUMMARY AND COMMENT
June 3, 2013
Joseph D. Tucker, MD, MA
A cross-sectional analysis involving 47,231 men who have sex with men in China demonstrated a high burden of both syphilis and HIV infection.
Reviewing:
Wu Z et al., Clin Infect Dis 2013 May 10
Muessig KE and Cohen MS., Clin Infect Dis 2013 May 10