HIV/AIDS Clinical Care: Archives

CORRECTION

Addendum: Does More HIV Testing Identify More New HIV Cases?Free

• June 22, 2009
• The Editors

An addendum to a summary published on May 22, 2009

SUMMARY AND COMMENT

HIV Viremia Linked with Lymphoma Risk in ART-Treated Patients

• June 22, 2009
• Abigail Zuger, MD

The more time that antiretroviral-treated patients had detectable viremia, the higher their risk for developing lymphoma, regardless of their CD4-cell counts.

• Reviewing:
• Zoufaly A et al., J Infect Dis 2009 Jul 1; 200:79 Sabin CA., J Infect Dis 2009 Jul 1; 200:8

SUMMARY AND COMMENT

Can Early ART Help to Protect HIV-Positive Children Against Vaccine-Preventable Illnesses?

• June 22, 2009
• Sonia Nagy Chimienti, MD

Among children with vertically transmitted HIV infection, those who initiated antiretroviral therapy by age 1 had better B-cell function and greater evidence of protection from childhood vaccines than did children who started ART later.

• Reviewing:
• Pensieroso S et al., Proc Natl Acad Sci U S A 2009 May 12; 106:7939

SUMMARY AND COMMENT

Should HIV Patients with Opportunistic Infections Receive Immediate ART?Free

• June 22, 2009
• Sonia Nagy Chimienti, MD

In a randomized trial, the incidence of AIDS progression or death by 48 weeks was significantly lower among patients who received antiretroviral therapy soon after their OI treatment had started than among those for whom ART was delayed.

• Reviewing:
• Zolopa AR et al., PLoS One 2009 May 18; 4:e5575

SUMMARY AND COMMENT

HIV Infection and the Risk for Carotid AtherosclerosisFree

• June 15, 2009
• Keith Henry, MD

In a cross-sectional study, HIV infection was independently associated with increased carotid-artery intima–media thickness, a marker of preclinical atherosclerosis, at a magnitude similar to that of traditional cardiovascular risk factors.

• Reviewing:
• Grunfeld C et al., AIDS 2009 May 18

SUMMARY AND COMMENT

A Profile of Hospitalized HIV-Positive Patients in Two U.S. CitiesFree

• June 8, 2009
• Sonia Nagy Chimienti, MD

Most HIV-positive patients hospitalized at two urban medical centers reported a lack of previous outpatient HIV care and no current use of antiretrovirals.

• Reviewing:
• Metsch LR et al., Am J Public Health 2009 Jun; 99:1045

SUMMARY AND COMMENT

CNS Penetration of ART and Cognitive Performance: An Unexpected Finding

• June 8, 2009
• Jennifer Johnson, MD, and Paul E. Sax, MD

Increased CNS penetration effectiveness of the ART regimen was associated with poorer neurocognitive outcomes, despite increased rates of CSF viral suppression.

• Reviewing:
• Marra CM et al., AIDS 2009 May 6

SUMMARY AND COMMENT

ART for HIV/TB-Coinfected Patients Taking Rifampicin: Efavirenz or Nevirapine?

• June 8, 2009
• Salim S. Abdool Karim, MD, PhD, and Tanuja Gengiah, M Clin Pharm, MS(Epi)

A study conducted in Thailand suggests that an efavirenz-based regimen might be preferable to a nevirapine-based one in HIV/TB-coinfected patients taking rifampicin.

• Reviewing:
• Manosuthi W et al., Clin Infect Dis 2009 Jun 15; 48:1752 Lalloo UG., Clin Infect Dis 2009 Jun 15; 48:1760

SUMMARY AND COMMENT

Growing HIV Epidemic in China Among MSM

• June 8, 2009
• Salim S. Abdool Karim, MD, PhD

Results from surveys conducted in 2006 and 2007 in Chongqing show worrisome increases in HIV prevalence among MSM who frequent bathhouses or saunas, those younger than 25, and those who are married.

• Reviewing:
• Feng L et al., J Acquir Immune Defic Syndr 2009 May 14

SUMMARY AND COMMENT

How Deep Are the Reservoirs of Antiretroviral Resistance?

• June 8, 2009
• Charles B. Hicks, MD

An assay that measures HIV-derived DNA in peripheral blood mononuclear cells detected more resistance mutations in more patients than did standard serum resistance testing.

• Reviewing:
• Ellis GM et al., J Acquir Immune Defic Syndr 2009 Apr 24