HIV/AIDS Clinical Care: Archives

SUMMARY AND COMMENT

Long-Term Nonprogressors and HIV Controllers: Definitions and Prevalence

• June 8, 2009
• Paul E. Sax, MD

Very few HIV-positive patients met strict criteria for immunologic stability, virologic control, or both, in a large, prospective cohort study in France.

• Reviewing:
• Grabar S et al., AIDS 2009 Jun 1; 23:1163

SUMMARY AND COMMENT

High Rate of New HIV Infection in Late Pregnancy

• June 8, 2009
• Keith Henry, MD

Among pregnant women in South Africa, repeat testing conducted between 36 and 40 weeks of gestation revealed new HIV infection in 3%.

• Reviewing:
• Moodley D et al., AIDS 2009 May 18

SUMMARY AND COMMENT

ART and HCV Activity

• June 1, 2009
• Rajesh T. Gandhi, MD

ART may decrease hepatic necroinflammatory activity in HIV/HCV-coinfected patients with CD4 counts >350 cells/mm³.

• Reviewing:
• Pascual-Pareja JF et al., AIDS 2009 May 15; 23:971

SUMMARY AND COMMENT

HIV Testing — Targeting High-Risk Populations

• June 1, 2009
• Charles B. Hicks, MD

In an innovative program of bathhouse-based HIV testing, 4% of participants were found to be HIV-infected.

• Reviewing:
• Daskalakis D et al., Clin Infect Dis 2009 Jun 1; 48:1609

SUMMARY AND COMMENT

No Harm, No Benefit from Maraviroc in Patients with Non-R5 HIV

• June 1, 2009
• Keith Henry, MD

The addition of maraviroc to optimized background therapy was well tolerated but conferred no virologic benefit in treatment-experienced patients with dual- or mixed-tropic virus.

• Reviewing:
• Saag M et al., J Infect Dis 2009 Jun 1; 199:1638

SUMMARY AND COMMENT

The Puzzle of CD4-Cell Depletion Despite Good Viral SuppressionFree

• June 1, 2009
• Abigail Zuger, MD

In some patients, CD4-cell counts fail to rise as expected. Could extensive lymph node fibrosis be responsible?

• Reviewing:
• Nies-Kraske E et al., J Infect Dis 2009 Jun 1; 199:1648

SUMMARY AND COMMENT

NPEP and High-Risk Behavior

• May 22, 2009
• Raphael J. Landovitz, MD

In an Australian cohort, use of nonoccupational postexposure prophylaxis did not increase high-risk behavior, but men who received such prophylaxis remained at high risk for HIV seroconversion.

• Reviewing:
• Poynten IM et al., AIDS 2009 Jun 1; 23:1119

SUMMARY AND COMMENT

Does More HIV Testing Identify More New HIV Cases?Free

• May 22, 2009
• Sonia Nagy Chimienti, MD

Retrospective analysis of New York City registry data demonstrated that the proportion of newly identified HIV cases varied significantly across testing sites during a period of increased Western blot testing.

• Reviewing:
• Hanna DB et al., J Acquir Immune Defic Syndr 2009 May 7

SUMMARY AND COMMENT

Are Raltegravir–Etravirine Interactions Underestimated?

• May 22, 2009
• Helmut Albrecht, MD

Several patients had lower-than-predicted raltegravir levels when the drug was coadministered with etravirine.

• Reviewing:
• Ménard A et al., AIDS 2009 Apr 27; 23:869

SUMMARY AND COMMENT

More on the Timing of ART Initiation During an Acute OI

• May 18, 2009
• Philip Grant, MD, and Andrew Zolopa, MD

A retrospective study conducted in Brazil adds to the evidence supporting early ART in patients with acute OIs.

• Reviewing:
• Croda J et al., Crit Care Med 2009 May; 37:1605