Study Population- Pregnant women at 14-34 weeks of gestation with CD4 T lymphocyte count at study entry of 200 or more cells per mm3
Study Regimen- During Pregnancy: 100 mg AZT orally 5 times daily
- During Labor: loading dose of 2 mg/kg AZT, followed by continuous infusion of 1 mg/kg until cord clamped
- For Newborns: 2 mg/kg AZT oral syrup every 6 hours starting 8 to 12 hours after birth and continuing until the infant is 6 weeks old
Study Results- Placebo Group: Estimated transmission rate: 25.5% (confidence interval, 18.4% to 32.5%)
- AZT-Treated Group: Estimated transmission rate: 8.3% (confidence interval, 3.9% to 12.8%)
- AZT Side Effects:
- No significant difference between treated and untreated mothers
- Mild, transient anemia greater in treated infants
- No other differences
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