Table 2. Step 2 analgesic agents

Agent Usual single dose (po) Dose interval Comments

Codeine 30-60 mg q4-6h Useful in PUD/gastritis and chronic liver disease
Codeine/acetaminophen 1-2 Tabs of 30/325 mg q4-6h Combination may permit lower dosage of opioid
Hydrocodone/acetaminophen or ASA 1-2 Tabs of 5/325 mg q4-6h 10 mg of hydrocodone equivalent to codeine 80 mg
Oxycodone/acetaminophen or ASA 1-2 Tabs of 5/325 mg q4-6h 10 mg of oxycodone equivalent to morphine 10 mg or codeine 90 mg po

Adapted with permission from The Medical Letter, 1993 Vol 35, p1.