| Agent |
Starting dose |
Effective dose range |
Comments |
|
| Fluoxetine |
10-20 mg qd |
20-80 mg qd |
T1/2=7-9d; most activating of SSRIs; headache, tremor, GI upset, anorgasmia |
| Sertraline |
25-50 mg qd |
50-200 mg qd |
T1/2=3-4d |
| Paroxetine |
20 mg qd |
20-50 mg qd |
T1/2=21h |
| Bupropion |
75 mg bid |
100-150 mg tid |
Activating; suppresses appetite; decreases seizure threshold |
| Venlafaxine |
75 mg qd |
75-175 mg bid |
GI upset, headache, anxiety, sleep disturbance |
| Trazodone |
50 mg qhs |
300 mg qd |
May require up to 500 mg qd for antidepressant effect; sedating; rare priapism |
|
