| Class |
Agent |
Dose |
Side effects |
|
| Phenothiazines |
Prochlorperazine |
10 mg po q6-8h or 25 mg pr q8-12h |
Sedation, hypotension, EPS |
|
Promethazine |
25-50 mg po or pr q 4-6h |
Sedation, hypotension, EPS, anticholinergic |
| Butyrophenones |
Haloperidol |
0.5-3 mg po q2-12h |
EPS, sedation |
| Benzodiazepines |
Lorazepam |
0.5-2 mg po or sl q6-8h |
Sedation |
| Corticosteroids (should be used adjuvantly as brief taper) |
Dexamethasone |
4-8 mg po bid for 2 days then taper |
Altered mental status, potential for immune and adrenal suppression |
| Serotonin antagonists |
Ondansetron |
4-8 mg po tid |
None |
|
Granisetron |
1 mg po bid |
|
| Benzamides |
Trimethobenzamide |
250 mg po tid-qid or 200 mg pr q6-8h |
Sedation, EPS |
|
Metoclopramide |
10-20 mg po qid |
Sedation, EPS |
| Cannabinoids |
Dronabinol |
2.5-10 mg po tid |
Effective only at higher doses, thus very sedating |
|
Marijuana |
As tolerated |
Mood-altering, dry mouth |
| Antihistamines |
Diphenhydramine |
25-50 mg po q4-6h |
Sedating, anticholinergic |
|
Hydroxyzine |
10-25 mg po q4-6h |
Sedating, anticholinergic |
| Anticholinergics |
Scopolamine patch |
1 patch q3d |
Currently unavailable |
|
