Table 1. Pharmacologic Characteristics of the NNRTIs

Nevirapine Delavirdine Loviride Efavirenz HBY 097

Half-life 25-30 hours 5.8 hours Unknown 40-50 hours 10-12 hours
Protein binding 60% 98% Unknown 99.5% Unknown
Effect on P450 Induces Inhibits No significant effect Induces Unknown
Dosage 200 mg daily for 14 days, then 400 mg daily 400 mg three times daily 100 mg three times daily 600 mg daily 250-750 mg three times daily