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Advantages Disadvantages All NNRTIs No cross resistance to nucleoside analogs Cross-resistance to other NNRTIs Relatively low threshold for development of resistance, especially if used alone or in suboptimal regimen Nevirapine Once or twice daily dosing Good CNS penetration Compatible with protease inhibitors Potential for pediatric use Rashes (17% mild, 7.6% severe) Reduces the effectiveness of oral contraceptives Delavirdine Less severe rash than with nevirapine Rash (18% mild, 3.6% severe) Three times daily dosing Poor CNS penetration Drug interactions Limited data regarding safety of combining with protease inhibitors Efavirenz Single daily dosing Well tolerated Good CNS activity CNS side effects Incompatible with clarithromycin Reduces the effectiveness of oral contraceptives Loviride Good safety profile Not available in the United States Three times daily dosing Limited antiviral and clinical benefit HBY 097 Not known Not known