Table 1. Codon changes associated with exposure to different classes of antiretroviral drugs. (The most significant mutations are in bold.)

Reverse Transcriptase Nucleoside Inhibitors Changes in the Reverse Transcriptase Gene
Zidovudine (AZT) 41, 67, 70, 215, 219
Didanosine (ddI) 65, 74, 184

Zalcitabine (ddC) 65, 69, 184
Lamivudine (3TC) 184
Stavudine (d4T) 50 (in vitro), 75
1592U89 65, 74, 115, 184
Non-Nucleoside Reverse Transcriptase Inhibitors Changes in the Reverse Transcriptase Gene
Nevirapine 103, 106, 108, 181, 188, 190
Loviride 103, 181
Delavirdine 181, 236
DMP-266 100, 108, 179, 181
Protease Inhibitors Changes in the Protease Gene
Saquinavir 10, 48, 54, 63, 71, 90
Ritonavir 20, 33, 36, 46, 54, 71, 82, 84, 90
Indinavir 10, 20, 24, 46, 54, 63, 64, 82, 84, 90
Nelfinavir 30, 35, 36, 46, 71, 77, 84, 88
141W94 10, 46, 47, 50, 84