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Type of Exposure Source Material Postexposure Prophylaxis Regimen Percutaneous Blood -- Highest risk Recommend AZT+3TC+IDV* -- Increased risk Recommend AZT+3TC,+/-IDV Bloody fluid or potentially infectious fluid or tissue** Offer AZT+3TC Mucous Membrane Blood Offer AZT+3TC,+/-IDV Bloody fluid or potentially infectious fluid or tissue** Offer AZT,+/-3TC Skin, with high-titer source patient, or prolonged contact, or compromised skin integrity, or extensive area Blood Offer AZT+3TC,+/-IDV Bloody fluid or potentially infectious fluid or tissue** Offer AZT, +/-3TC

*AZT 200 mg three times a day, 3TC 150 mg two times a day, indinavir (IDV) 800 mg three times a day.**Potentially infectious fluid or tissue includes: semen, vaginal secretions, and cerebrospinal, synovial, pleural, peritoneal, pericardial, and aminiotic fluid.Adapted from MMWR June 7, 1996, Vol. 45 No. 22, p. 471.