| Diagnosis |
Disease Stage |
Clinical Symptoms |
Neurologic Signs |
Standard Therapy |
Experimental Therapy |
|
| DSP |
Late |
Distal symmetric numbness, tingling, and burning sensations; paresthesias or aching |
Stocking-glove sensory loss, depressed or absent ankle reflexes |
Neurotoxin withdrawal, analgesics, topical agents, anticonvulsants, tricyclic antidepressants, acupuncture |
rhNGF, Lidoderm (5% lidocaine gel), prouridine |
| IDP |
Early to late |
Progressive weakness, paresthesias |
Muscle weakness, mild sensory loss, areflexia |
Early: Corticosteroids, plasmapheresis, high-dose intravenous immunoglobulinLate: Ganciclovir, foscarnet, cidofovir (late-stage HIV disease) |
None |
| MM |
Early (limited)Late (progressive) |
Foot or wrist drop, facial weakness, focal pain |
Multifocal cranial and peripheral neuropathies |
Early: NoneLate: Ganciclovir, foscarnet, and cidofovir (singly or in combination) |
None |
| PP |
Late |
Lower extremity weakness, sphincter dysfunction, paresthesias |
Flaccid paraparesis; saddle distribution anesthesia; depressed ankle and knee reflexes |
Ganciclovir, foscarnet, and cidofovir (singly or in combination) |
None |
| AN |
Late to early |
Orthostatic dizziness, syncope, diarrhea, anhidrosis, palpitations, impotence, urinary dysfunction |
Orthostatic hypotension, pupillary abnormalities, sweating dysfunction, resting tachycardia |
Discontinuation of offending drugs, fluorocortisone, antiarrhythmic agents, fluid and electrolyte replacement |
None |
|
