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Medication Usual Initial Dose Usual Maintenance Dose Miscellaneous Antihyperlipidemics Statins Atorvastatin 10-20 mg daily 20-80 mg daily A, B Lovastatin 10-20 mg daily 20-80 mg daily A, B Pravastatin 10-20 mg daily 20-40 mg daily B Simvastatin 5-10 mg daily 10-80 mg daily A, B Antihyperlipidemics Fibrins Fenofibrate 67 mg daily 134-201 mg daily A, B Gemfibrozil 600 mg daily 1200 mg daily A, B Hypoglycemics Sulfonureas Glipizide 2.5 mg daily Up to 40 mg daily, divided bid C Glyburide 1.25 mg daily Up to 20 mg daily, divided bid C Tolazamide 50-100 mg daily Up to 1000 mg daily, divided bid D Hypoglycemics Insulin Sensitizers Metformin 500 mg daily Up to 2500 mg daily, divided bid E Troglitazone 200 mg daily Up to 600 mg daily, divided bid F

A denotes metabolized by CYP3A4; B, infrequent hepatotoxicity and rhabdomyolysis, follow LFTs while on therapy; C, long half-life, may accumulate and cause persistent hypoglycemia in elderly or frail patients; D, short half-life; E, Life-threatening lactic acidosis seen especially in individuals with renal insufficiency or hypoperfusion states, use with extreme caution because of potential for lactic acidosis with NRTIs; F, Life-threatening idiosyncratic hepatotoxicity seen with troglitazone, do not use in patients with a history of hepatic dysfunction or serum transaminase >1.5 times normal. Source: PDR