Table 2. Common Side Effects of Interferons and Ribavirin

TYPE OF SIDE EFFECT INTERFERONS RIBAVIRIN

SYSTEMIC Fevers Dry mouth
Chills Nausea
Myalgias Fatigue
Fatigue
NEUROPSYCHIATRIC Depression Depression
Irritability Irritability
Cognitive dysfunction Cognitive dysfunction
ENDOCRINOLOGIC Thyroiditis
Diabetes exacerbation
DERMATOLOGIC Dry skin Dry skin
Rash Rash (occasionally hypersensitivity type)
Psoriasis exacerbation
Cutaneous necrosis
Alopecia
HEMATOLOGIC Thrombocytopenia Hemolytic anemia
Neutropenia
OTHER Retinopathy Teratogenicity
Exacerbation of autoimmune processes (e.g., IBD and RA) Exacerbation of underlying cardiac disease with severe anemia

IBD = inflammatory bowel disease; RA = rheumatoid arthritis