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Tuberculosis and HIV

HIV has had a substantial effect on the incidence, clinical manifestations, treatment, and outcome of TB. Globally, HIV and TB are the 2 leading infectious causes of death. Coinfection with these pathogens can be particularly devastating, especially in the developing world, where the burden of disease is high and access to effective therapy is low. This article reviews issues of epidemiology, disease pathology, clinical presentation, diagnosis, and treatment of TB in HIV-infected patients.