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New DHHS Recommendation Regarding Entecavir in HIV/HBV-Coinfected Patients
On April 30, 2007, the U.S. Department of Health and Human Services revised its guidelines for using entecavir in patients coinfected with HIV and hepatitis B virus (HBV). The new recommendation states that clinicians should not use entecavir to treat HBV in coinfected patients unless those patients also receive antiretroviral therapy. This recommendation is based on a case series of three coinfected patients who experienced a 1-log reduction in HIV viral load while receiving entecavir without concomitant HIV treatment (ACC Mar 5 2007).
Source: U.S. Department of Health and Human Services. Supplement to the Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents — October 10, 2006. April 30, 2007. Available at: http://www.aidsinfo.nih.gov/contentfiles/EntecavirInHIV.pdf. Accessed May 4, 2007.
Published in AIDS Clinical Care May 7, 2007