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- Top Stories of 2009: Editors' Choice
HIV/AIDS Clinical Care Top Stories of 2009: Editors' Choice
MEETING REPORT
When to Start ART: Two Major Cohort Studies Published
- April 17, 2009
- Paul E. Sax, MD
- HIV/AIDS Clinical Care
One study suggests that treatment should be started before the CD4 count falls below 350 cells/mm3; the other suggests before 500 cells/mm3.
- Reviewing:
- Kitahata MM et al. N Engl J Med 2009 Apr 1
Sax PE and Baden LR. N Engl J Med 2009 Apr 1
When To Start Consortium. Lancet 2009 Apr 9
Wood R and Lawn SD. Lancet 2009 Apr 9
MEETING REPORT
Early ART Initiation Improves Survival in Resource-Limited Settings
- August 31, 2009
- Gerald H. Friedland, MD
- HIV/AIDS Clinical Care
New findings from Haiti (described at IAS 2009) support starting ART when CD4 counts fall below 350 cells/mm3 — the same threshold that is recommended in resource-rich settings.
SUMMARY AND COMMENT
A Glimmer of Hope for HIV Vaccines
- October 22, 2009
- Frances H. Priddy, MD, MPH, and Carlos del Rio, MD
- HIV/AIDS Clinical Care
A large trial has shown that a vaccine can protect against HIV acquisition. The task now is to figure out how to build on this initial success.
- Reviewing:
- Rerks-Ngarm S et al. N Engl J Med 2009 Oct 20
Dolin R. N Engl J Med 2009 Oct 20
MEETING REPORT
First (Sort of) Positive Anti-HIV Microbicide Trial
- March 9, 2009
- Carlos del Rio, MD
- HIV/AIDS Clinical Care
Promising results from HPTN 035, a phase II trial of two microbicides, were reported at the 2009 Retrovirus Conference.
SUMMARY AND COMMENT
Stem-Cell Transplantation Enables Long-Term HIV Control
- February 13, 2009
- Abigail Zuger, MD
- HIV/AIDS Clinical Care
A leukemia patient lost his CCR5 receptors and achieved remission of both leukemia and HIV infection.
- Reviewing:
- Hütter G et al. N Engl J Med 2009 Feb 12; 360:692
Levy JA. N Engl J Med 2009 Feb 12; 360:724
SUMMARY AND COMMENT
Is Elimination of a Generalized HIV Epidemic Possible?
- December 15, 2008
- Salim S. Abdool Karim, MD, PhD
- HIV/AIDS Clinical Care
A mathematical model using data from South Africa suggests that the HIV epidemic in this region could be eliminated with rapid scale-up of universal voluntary HIV testing and immediate ART.
- Reviewing:
- Granich RM et al. Lancet 2008 Nov 26
MEETING REPORT
Concomitant HIV/TB Treatment Improves Survival
- March 9, 2009
- Paul E. Sax, MD
- HIV/AIDS Clinical Care
Delaying antiretroviral therapy until after TB treatment has been completed is associated with increased mortality risk.
MEETING REPORT
Maternal ART Reduces Transmission of HIV through Breast-Feeding
- August 31, 2009
- Judith Feinberg, MD
- HIV/AIDS Clinical Care
In a study conducted in Botswana (and reported at IAS 2009), the rate of mother-to-child transmission was only 1% among breast-feeding women who received ART through 6 months postpartum.
SUMMARY AND COMMENT
Impressive Results with Raltegravir in Treatment-Naive HIV Patients
- August 10, 2009
- Paul E. Sax, MD
- HIV/AIDS Clinical Care
Rates of virologic suppression were similar between raltegravir and efavirenz, but drug-related adverse events were less common with raltegravir.
- Reviewing:
- Lennox JL et al. Lancet 2009 Aug 3
Emery S and Winston A. Lancet 2009 Aug 3
SUMMARY AND COMMENT
IL-2 and HIV: Two Definitive Studies Published
- October 14, 20099
- Rajesh T. Gandhi, MD
- HIV/AIDS Clinical Care
Although interleukin-2 raises CD4-cell counts in HIV-infected patients, it does not improve clinical outcomes.
- Reviewing:
- The INSIGHT–ESPRIT Study Group and SILCAAT Scientific Committee. N Engl J Med 2009 Oct 15; 361:1548
